tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2016-3-11-16tumors-255Research ArticleФУНДАМЕНТАЛЬНАЯ ОНКОЛОГИЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАFUNDAMENTAL ONCOLOGY AND EXPERIMENTAL MEDICINEМорфологические аспекты кровоизлияний в опухоли гипофизаMorphological feature of haemorrhages into pituitary adenomasКУТИНМ. А.KUTINM. A.

нейрохирург, врач нейроонкологического отделения

MD, PhD, neurosurgeon

Kutin@nsi.ruРОТИНД. Л.ROTIND. L.

д. м.н., заведующий отделением патологической анатомии

MD, PhD, DSc, morphologist

d.rotin@mknc.ruШИШКИНАЛ. В.SHISHKINAL. V.

д. м.н., ведущий научный сотрудник отделения нейроморфологии

MD, PhD, DSc, morphologist

LSHISHKINA@nsi.ruАСТАФЬЕВАЛ. И.ASTAF’EVAL. I.

д. м.н., эндокринолог, врач нейроонкологического отделения

MD, PhD, DSc, endocrinologist

last@nsi.ruКАДАШЕВБ. А.KADASHEVB. A.

д. м.н., профессор

MD, PhD, DSc, professor neurosurgeon

kadashev@nsi.ruКАЛИНИНП. Л.KALININP. L.

д.м.н., нейрохирург, заведующий 8-го нейроонкологического отделения

MD, PhD, DSc, neurosurgeon

pkalinin@nsi.ruФОМИЧЁВД. В.FOMICHOVD. V.

к.м.н., нейрохирург, врач нейроонкологического отделения

MD, PhD, neurosurgeon

dfomicev@nsi.ruШАРИПОВО. И.SHARIPOVO. I.

к.м.н., нейрохирург, врач нейроонкологического отделения

MD, PhD, neurosurgeon

osharipov@nsi.ruСИДОРУКЕ. В.SIDORUKE. V.

студентка

medical student

ekaterina.sidoruk@gmail.comНИИ нейрохирургии им. акад. Н. Н. Бурденко, МоскваРоссияBurdenko Neurosurgical institute, MoscowRussian FederationМКНЦ ДЗМ, МоскваРоссияMoscow scientific clinical center, RussiaRussian FederationНИИ нейрохирургии им. акад. Н. Н. Бурденко, МоскваРоссияBurdenko Neurosurgical institute, MoscowRussian FederationПервый МГМУ им. И. М. Сеченова, МоскваРоссияSechenov First Moscow State Medical UniversityRussian Federation201614102016031116Copyright © КУТИН М.А., РОТИН Д.Л., ШИШКИНА Л.В., АСТАФЬЕВА Л.И., КАДАШЕВ Б.А., КАЛИНИН П.Л., ФОМИЧЁВ Д.В., ШАРИПОВ О.И., СИДОРУК Е.В., 20162016КУТИН М.А., РОТИН Д.Л., ШИШКИНА Л.В., АСТАФЬЕВА Л.И., КАДАШЕВ Б.А., КАЛИНИН П.Л., ФОМИЧЁВ Д.В., ШАРИПОВ О.И., СИДОРУК Е.В.KUTIN M.A., ROTIN D.L., SHISHKINA L.V., ASTAF’EVA L.I., KADASHEV B.A., KALININ P.L., FOMICHOV D.V., SHARIPOV O.I., SIDORUK E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/255

Авторами статьи установлены морфологические особенности аденом гипофиза, в строму которых происходят кровоизлияния. Исследованы тинкториальные свойства, макро- и микроскопические характеристики. С помощью иммуногистохимического исследования определён уровень экспрессии VEGF, EGFR, циклина D1, белка p53, что позволило предположить непосредственную причину и патогенез питуитарных кровоизлияний.

Morphological features of pituitary adenomas, into which stroma haemorrhages take place, have been established by authors of the article. Tinctorial, macro- and microscopic characteristics have been researched. By an immunohistochemical research a level of expression of VEGF, EGFR, cyclin D1, protein p53 had been determine, that allowed to suppose an immediate reason and pathogenesis of haemorrhages into pituitary adenomas.

гипофизаденомакровоизлияниепитуитарная апоплексияморфологияhypothesisadenomahaemorrhagepituitary apoplexymorphologyReferencesde Heide L.J., van Tol K.M., Doorenbos B. Pituitary apoplexy presenting during pregnancy. Neth J Med. Nov 2004;62(10):393–396.de Heide L.J., van Tol K.M., Doorenbos B. Pituitary apoplexy presenting during pregnancy. Neth J Med. Nov 2004;62(10):393–396.Ito Y., Takano S, Muroi A., Matsumura A. [Massive subarachnoid hemorrhage and intraventricular hemorrhage after transsphenoidal surgery of pituitary adenoma: a case report]. No shinkei geka. Neurological surgery. Sep 2009;37(9): 887–892.Ito Y., Takano S, Muroi A., Matsumura A. [Massive subarachnoid hemorrhage and intraventricular hemorrhage after transsphenoidal surgery of pituitary adenoma: a case report]. No shinkei geka. Neurological surgery. Sep 2009;37(9): 887–892.Serhal D., Weil R.J., Hamrahian A.H. Evaluation and management of pituitary incidentalomas. Cleveland Clinic journal of medicine. Nov 2008;75(11):793–801.Serhal D., Weil R.J., Hamrahian A.H. Evaluation and management of pituitary incidentalomas. Cleveland Clinic journal of medicine. Nov 2008;75(11):793–801.Salehi F., Kovacs K., Cusimano M.D., et al. Immunohistochemical expression of nestin in adenohypophysial vessels during development of pituitary infarction. Journal of neurosurgery. Jan 2008;108(1):118–123, doi: 10.3171/jns/2008/108/01/0118.Salehi F., Kovacs K., Cusimano M.D., et al. Immunohistochemical expression of nestin in adenohypophysial vessels during development of pituitary infarction. Journal of neurosurgery. Jan 2008;108(1):118–123, doi: 10.3171/jns/2008/108/01/0118.Kim S.H., Lee K.C. Cranial nerve palsies accompanying pituitary tumour. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia. Dec 2007;14(12):1158– 1162, doi: 10.1016/j.jocn.2006.07.016.Kim S.H., Lee K.C. Cranial nerve palsies accompanying pituitary tumour. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia. Dec 2007;14(12):1158– 1162, doi: 10.1016/j.jocn.2006.07.016.Huang D.Q., Li W.R., Ou X.Y. [Transsphenoidal endoscopic management of pituitary apoplexy sphenoid mucocele]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. Apr 2006;41(4):306–307.Huang D.Q., Li W.R., Ou X.Y. [Transsphenoidal endoscopic management of pituitary apoplexy sphenoid mucocele]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. Apr 2006;41(4):306–307.Carsote M., Chirita C., Dumitrascu A., Hortopan D., Fica S., Poiana C. Pituitary incidentalomas – how often is too often? J Med Life. Jan-Mar 2009;2(1):92–97.Carsote M., Chirita C., Dumitrascu A., Hortopan D., Fica S., Poiana C. Pituitary incidentalomas – how often is too often? J Med Life. Jan-Mar 2009;2(1):92–97.Xing B., Deng K., Ren Z.Y., et al. Magnetic resonance imaging characteristics and surgical results of adrenocorticotropinsecreting pituitary adenomas. Chinese medical sciences journal = Chung-kuo i hsueh k’o hsueh tsa chih / Chinese Academy of Medical Sciences. Mar 2008;23(1):44–48.Xing B., Deng K., Ren Z.Y., et al. Magnetic resonance imaging characteristics and surgical results of adrenocorticotropinsecreting pituitary adenomas. Chinese medical sciences journal = Chung-kuo i hsueh k’o hsueh tsa chih / Chinese Academy of Medical Sciences. Mar 2008;23(1):44–48.Hiroi N., Ichijo T., Shimojo M., Ueshiba H., Tsuboi K., Miyachi Y. Pituitary apoplexy caused by luteinizing hormonereleasing hormone in prolactin-producing adenoma. Internal medicine (Tokyo, Japan). Aug 2001;40(8):747–750.Hiroi N., Ichijo T., Shimojo M., Ueshiba H., Tsuboi K., Miyachi Y. Pituitary apoplexy caused by luteinizing hormonereleasing hormone in prolactin-producing adenoma. Internal medicine (Tokyo, Japan). Aug 2001;40(8):747–750.Haboubi H., Azam I., Edavalath M., Redfern R.M., Price D.E., Stephens J.W. Apoplexy in a corticotrophin-secreting pituitary macroadenoma: a case report and review of the literature. QJM. Aug 2010;103(8):607–609, doi: 10.1093/ qjmed/hcp197.Haboubi H., Azam I., Edavalath M., Redfern R.M., Price D.E., Stephens J.W. Apoplexy in a corticotrophin-secreting pituitary macroadenoma: a case report and review of the literature. QJM. Aug 2010;103(8):607–609, doi: 10.1093/ qjmed/hcp197.Shou X.F., Wang Y.F., Li S.Q., et al. Microsurgical treatment for typical pituitary apoplexy with 44 patients, according to two pathological stages. Minim Invasive Neurosurg. Oct 2009;52(5–6):207–211, doi: 10.1055/s‑0029–1241848.Shou X.F., Wang Y.F., Li S.Q., et al. Microsurgical treatment for typical pituitary apoplexy with 44 patients, according to two pathological stages. Minim Invasive Neurosurg. Oct 2009;52(5–6):207–211, doi: 10.1055/s‑0029–1241848.Baglin G., Betermiez P., Bertout A., Toussaint P., Bremond- Gignac D., Milazzo S. [Pituitary apoplexy and severe bilateral visual loss: a case report]. J Fr Ophtalmol. Oct 2009;32(8):572–576, doi: 10.1016/j.jfo.2009.04.019.Baglin G., Betermiez P., Bertout A., Toussaint P., Bremond- Gignac D., Milazzo S. [Pituitary apoplexy and severe bilateral visual loss: a case report]. J Fr Ophtalmol. Oct 2009;32(8):572–576, doi: 10.1016/j.jfo.2009.04.019.Sibal L., Ball S.G., Connolly V., et al. Pituitary apoplexy: a review of clinical presentation, management and outcome in 45 cases. Pituitary. 2004;7(3):157–163, doi: 10.1007/ s11102– 005–1050–3.Sibal L., Ball S.G., Connolly V., et al. Pituitary apoplexy: a review of clinical presentation, management and outcome in 45 cases. Pituitary. 2004;7(3):157–163, doi: 10.1007/ s11102– 005–1050–3.Semple P.L., Jane J.A., Jr., Laws E.R., Jr. Clinical relevance of precipitating factors in pituitary apoplexy. Neurosurgery. Nov 2007;61(5):956–961; discussion 961–952. 10.1227/01. neu.0000303191.57178.2a.Semple P.L., Jane J.A., Jr., Laws E.R., Jr. Clinical relevance of precipitating factors in pituitary apoplexy. Neurosurgery. Nov 2007;61(5):956–961; discussion 961–952. 10.1227/01. neu.0000303191.57178.2a.Eaton H.J., Phillips P.J., Hanieh A., Cooper J., Bolt J., Torpy D.J. Rapid onset of pituitary apoplexy after goserelin implant for prostate cancer: need for heightened awareness. Internal medicine journal. Jul 2001;31(5):313–314.Eaton H.J., Phillips P.J., Hanieh A., Cooper J., Bolt J., Torpy D.J. Rapid onset of pituitary apoplexy after goserelin implant for prostate cancer: need for heightened awareness. Internal medicine journal. Jul 2001;31(5):313–314.Semple P.L., De Villiers J.C., Bowen R.M., Lopes M.B., Laws E.R., Jr. Pituitary apoplexy: do histological features influence the clinical presentation and outcome? J Neurosurg. Jun 2006;104(6):931–937, doi: 10.3171/jns.2006.104.6.931.Semple P.L., De Villiers J.C., Bowen R.M., Lopes M.B., Laws E.R., Jr. Pituitary apoplexy: do histological features influence the clinical presentation and outcome? J Neurosurg. Jun 2006;104(6):931–937, doi: 10.3171/jns.2006.104.6.931.McFadzean R.M., Doyle D., Rampling R., Teasdale E., Teasdale G. Pituitary apoplexy and its effect on vision. Neurosurgery. Nov 1991;29(5):669–675.McFadzean R.M., Doyle D., Rampling R., Teasdale E., Teasdale G. Pituitary apoplexy and its effect on vision. Neurosurgery. Nov 1991;29(5):669–675.Fraioli B., Esposito V., Palma L., Cantore G. Hemorrhagic pituitary adenomas: clinicopathological features and surgical treatment. Neurosurgery. Nov 1990;27(5):741– 747; discussion 747–748.Fraioli B., Esposito V., Palma L., Cantore G. Hemorrhagic pituitary adenomas: clinicopathological features and surgical treatment. Neurosurgery. Nov 1990;27(5):741– 747; discussion 747–748.Cardoso E.R., Peterson E.W.. Pituitary apoplexy: a review. Neurosurgery. Mar 1984;14(3):363–373.Cardoso E.R., Peterson E.W.. Pituitary apoplexy: a review. Neurosurgery. Mar 1984;14(3):363–373.Muller W. PH. Zur Klinik und Autologie der Massenblutungen in Hypophysenadenome. – Dtsch A Nervenklinik. – 1953. – 170. – p. 326–336. 1953.Muller W. PH. Zur Klinik und Autologie der Massenblutungen in Hypophysenadenome. – Dtsch A Nervenklinik. – 1953. – 170. – p. 326–336. 1953.Grant F.C. The surgical treatment of pituitary adenomas. JAMA. – 1939. – 113. – p. 1279– 1282. 1939.Grant F.C. The surgical treatment of pituitary adenomas. JAMA. – 1939. – 113. – p. 1279– 1282. 1939.Poussant T.Y. BP, Anthony D.C. Et al. Hemorrhagic pituitary adenomas of adolescence. – Am J Neuroradiol. – 1996. – Nov. – 17. – p. 1907–1912. 1996.Poussant T.Y. BP, Anthony D.C. Et al. Hemorrhagic pituitary adenomas of adolescence. – Am J Neuroradiol. – 1996. – Nov. – 17. – p. 1907–1912. 1996.Chang C.V., Felicio A.C., Toscanini A.C., Teixeira M.J., Cunha- Neto M.B. Pituitary tumor apoplexy. Arquivos de neuropsiquiatria. Jun 2009;67(2a):328–333.Chang C.V., Felicio A.C., Toscanini A.C., Teixeira M.J., Cunha- Neto M.B. Pituitary tumor apoplexy. Arquivos de neuropsiquiatria. Jun 2009;67(2a):328–333.

The authors declare that there are no conflicts of interest present.