tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2016-2-72-80tumors-236Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSРегорафениб: новый препарат для лечения метастатического колоректального ракаRegorafenib: a novel drug for metastatic colorectal cancer treatmentСекачеваМарина ИгоревнаSekachevaMarina Igorevna

д. м.н., онколог, ученый секретарь

MD, PhD, DSc, oncologist, academic secretary

sekach_rab@mail.ruРоссийский научный центр хирургии им. акад. Б. В. ПетровскогоРоссияPetrovsky National Research Centre of SurgeryRussian Federation201602082016027280Copyright © Секачева М.И., 20162016Секачева М.И.Sekacheva M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/236

Метастатический колоректальный рак – огромная, социально значимая проблема здравоохранения. Разработка новых подходов к лечению, внедрение новейших препаратов, особенно таргетного действия позволяет увеличить продолжительность жизни таких пациентов. Недавно появившийся в арсенале онкологов препарат регорафениб достоверно улучшает результаты лечения в этой сложной группе больных, обладая приемлемым профилем токсичности. В статье представлены данные крупных исследований, проведенных для изучения свойств и эффектов регорафениба. Всесторонне рассмотрены полученные результаты по изменению показателей общей выживаемости, выживаемости без прогрессирования, объективного ответа, спектр нежелательных явлений.

Metastatic colorectal cancer is a serious medical and social problem. Development of new treatment approaches, drugs, especially targeted drugs, leads to the instantly increasing of survival in this disease. Regorafenib is recently approved for use in advanced metastatic colorectal cancer. This drug significantly improves treatment results with acceptable safety profile. In this review results of large controlled studies of regorafenib in colorectal cancer are discussed. Data on overall survival, progression-free survival, objective response rate and safety profile are consecutively evaluated.

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The authors declare that there are no conflicts of interest present.