tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2016-2-22-27tumors-229Research ArticleФУНДАМЕНТАЛЬНАЯ ОНКОЛОГИЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАFUNDAMENTAL ONCOLOGY AND EXPERIMENTAL MEDICINEОпухолевые стволовые клетки при раке молочной железы. Роль в патогенезе и подходы к терапииThe tumor stem cells in breast cancer. The role in pathogenesis and approaches to therapyТитовКонстантин СергеевичTitovKonstantin Sergeevich

д. м.н., заведующий онкохирургическим отделением опухолей кожи и мягкихтканей; доцент кафедры онкологии и лучевой терапии лечебного факультета

MD, RhD, DSc, head of the Оnсоsurgery Department tumors of skin and soft fabrics

ks-titov@mail.ruОганесянАни ПогосовнаOganesyanAni Pogosovna

студентка 6 курса лечебного факультета

student

ani101192@mail.ruРотинДаниил ЛеонидовичRotinDaniil Leonidovich

д. м.н., заведующий патoлогоанатомическим отделением

MD, RhD, DSc, head of the Patomorphologic Department

d.rotin@mknc.ruРябчиковДенис АнатольевичRyabchickovDenis Anatolevich

к. м.н., старший научный сотрудник хирургического отделения опухолей молочных желез

MD, RhD, assistant professor Оnсоsurgery Department tumors of breast

dr.denisr@mail.ruЛепковаНаталья ВасильевнаLepkovaNatalia Vasilevna

к. м.н., доцент кафедры онкологии и лучевой терапии лечебного факультета

MD, RhD, assistant professor of the Department of Oncology and Radiation Therapy

eczema70@mail.ruМосковский клинический научный центр Департамента здравоохранения г. Москвы; Российский национальный исследовательский медицинский университет им. Н. И. Пирогова Минздрава РФРоссияMoscow Clinical Research Centr, assistant professor of the Department of Oncology and Radiation Therapy Russian National Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет им. Н. И. Пирогова Минздрава РФРоссияRussian National Medical UniversityRussian FederationМосковский клинический научный центр Департамента здравоохранения г. МосквыРоссияMoscow Clinical Research CentrRussian FederationРоссийский онкологический научный центр им. Н. Н. Блохина Минздрава РФРоссияN. N. Вlokhin Russian Сancer Research CentreRussian Federation201601082016022227Copyright © Титов К.С., Оганесян А.П., Ротин Д.Л., Рябчиков Д.А., Лепкова Н.В., 20162016Титов К.С., Оганесян А.П., Ротин Д.Л., Рябчиков Д.А., Лепкова Н.В.Titov K.S., Oganesyan A.P., Rotin D.L., Ryabchickov D.A., Lepkova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/229

Рак молочной железы занимает лидирующее место среди всех онкологических заболеваний у женщин в мире, в т. ч. и в России. Несмотря на большие достижения в комплексном лечении, к сожалению, отдаленные метастазы рака молочной железы могут развиваться у больных на ранних стадиях заболевания. Данный феномен может быть объяснен новой теорией опухолевых стволовых клеток, способных в течение неограниченного периода времени делиться и поддерживать дальнейшее развитие первичной опухоли. В настоящем обзоре представлены концепция опухолевых стволовых клеток, их клиническое и прогностическое значение в патогенезе рака молочной железы, влияние на развитие резистентности к цитостатическим препаратам, а также перспективы новых и эффективных стратегий и подходов к системной противоопухолевой терапии рака молочной железы.

The breast cancer takes the leading position among all women cancers in the world and the Russian Federation. Despite great advances in treatment, unfortunately, distant metastasis of breast cancer may develop in patients at early stages of disease. This phenomenon can be explained by the new theory of tumor stem cells, capable of an unlimited period of time to share and support the development of a primary tumor. This review presents the concept of tumor stem cells, their clinical and prognostic significance in the breast cancer pathogenesis, the impact on the development of resistance to cytotoxic drugs and prospects for new and effective strategies and approaches to systemic anticancer therapy for breast cancer.

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The authors declare that there are no conflicts of interest present.