tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2016-1-5-9tumors-218Research ArticleФУНДАМЕНТАЛЬНАЯ ОНКОЛОГИЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАFUNDAMENTAL ONCOLOGY AND EXPERIMENTAL MEDICINEРОЛЬ ИНТЕГРИНОВ В ИНВАЗИИ И МЕТАСТАЗИРОВАНИИ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ КОЖИTHE ROLE INTEGRINS IN INVASII AND METASTATIC SKIN OF MALIGNANT TUMORSТитовК. С.TitovK. S.

д.м.н., заведующий онкохирургическим отделением опухолей кожи и мягких тканей; доцент кафедры онкологии и лучевой терапии 

MD, RhD, DSc, head of the Оnсоsurgery Department tumors of skin and soft fabrics; assistant professor of the Department of Oncology and Radiation Therapy

 

ks-titov@mail.ruРотинД. Л.RotinD. L.

д.м.н., заведующий патoлогоанатомическим отделением

MD, RhD, DSc, head of the Patomorphologic Department

d.rotin@mknc.ruКазаковА. М.KazakovA. M.

студент 4 курса лечебного факультета 

 

student

hordavii@yandex.ruЩербаковаЕ. А.SherbakovaE. A.

врач-терапевт гериатрического отделения

doctor of the Geriatric Department

vitalik.70@inbox.ruМосковский клинический научного центр Департамента здравоохранения г. Москвы Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава РФРоссияMoscow Clinical Research Centr Russian National Medical UniversityRussian FederationМосковский клинический научного центр Департамента здравоохранения г. МосквыРоссияMoscow Clinical Research CentrRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава РФРоссияRussian National Medical UniversityRussian Federation2016020620160159Copyright © Титов К.С., Ротин Д.Л., Казаков А.М., Щербакова Е.А., 20162016Титов К.С., Ротин Д.Л., Казаков А.М., Щербакова Е.А.Titov K.S., Rotin D.L., Kazakov A.M., Sherbakova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/218

Злокачественные опухоли кожи занимают лидирующее место в онкологической заболеваемости во всем мире. На сегодняшний день, благодаря развитию молекулярной биологии и генетики, становится понятным, что данные опухоли гетерогенны, имеют разные биологические характеристики, что влияет на прогноз заболевания и выбор тактики лечения. К таким изменениям относятся рецепторы интегринов, различная экспрессия которых может влиять на процессы инвазии и метастазирования. Предлагаем обзор современного понимания влияния интергинов на прогрессию опухолей кожи и разработки новых подходов к противоопухолевой терапии.

Malignant tumors of skin take the leading place in neoplastic incidence worldwide. Currently, concerning the development of molecular biology and genetics, it becomes clear that these tumors are heterogenic and have different biological characteristics that of prognostic and predictive significance. Various degree of integrin receptors expression, which can influence processes of an invasion and metastasis, belongs to such changes. We review the problem of modern understanding of the integrin’s influence on skin tumor progression and development of new approaches for antineoplastic therapy application.

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The authors declare that there are no conflicts of interest present.