tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncowebtumors-172Research ArticleСтатьиСтволовые опухолевые клетки рака толстой кишкиФедянинМихаил Юрьевич

к. м.н., врач-онколог отделения клинической фармакологии и химиотерапии,

г. Москва

fedianinmu@mail.ruХмельковаДарья Николаевна

н. с. лаборатории трансляционных исследований и персонализированной медицины Центра живых систем,

Московская область, г. Долгопрудный

darya.khmelkova@gmail.comСеребрийскаяТатьяна Сауловна

к. б.н., с. н.с. лаборатории трансляционных исследований и персонализированной медицины Центра живых систем,

Московская область, г. Долгопрудный

ts.serebriyskaya@gmail.comНикольскаяТатьяна Анатольевна

к. б.н., зав. лабораторией трансляционных исследований и персонализированной медицины Центра живых систем,

Московская область, г. Долгопрудный

ТюляндинСергей Алексеевич

д. м.н., профессор, зав. отделением клинической фармакологии и химиотерапии,

г. Москва

stjulandin@mail.ruФГБУ «Российский онкологический научный центр им. Н. Н. Блохина»Russian FederationМФТИRussian Federation20152111201504s27181Copyright © Федянин М.Ю., Хмелькова Д.Н., Серебрийская Т.С., Никольская Т.А., Тюляндин С.А., 20152015Федянин М.Ю., Хмелькова Д.Н., Серебрийская Т.С., Никольская Т.А., Тюляндин С.А.Федянин М.Ю., Хмелькова Д.Н., Серебрийская Т.С., Никольская Т.А., Тюляндин С.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/172

Ранее механизм канцерогенеза рака толстой кишки представлялся процессом последовательного накопления аберраций в генах APC, TP53, TGF , активации сигнального пути MAPK [1]. Это клинически реализовалось в формировании аденомы с последующей трансформацией в злокачественную опухоль. Однако к настоящему времени показано генетическое разнообразие аденокарцином толстой кишки, каждый подтип которой развивается по своему определенному генетически и/или эпигенетически опосредованному пути канцерогенеза [2]. В последнее десятилетие все чаще появляются работы, посвященные теории стволовых опухолевых клеток – только небольшая фракция опухолевых клеток способна инницировать рост опухоли. Данные клетки способны не только дифференцироваться в более зрелые формы опухолевых клеток, но и поддерживают собственный пул клеток – способность к самообновлению [3]. Кроме этого, данные клетки отличаются большей резистентностью к химиотерапии.

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The authors declare that there are no conflicts of interest present.