tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2013-1-3-14tumors-17Research ArticleФУНДАМЕНТАЛЬНАЯ ОНКОЛОГИЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАFUNDAMENTAL ONCOLOGY AND EXPERIMENTAL MEDICINEРОЛЬ МИКРО-РНК ПРИ СОЛИДНЫХ ОПУХОЛЯХRole of microRNAs in solid tumors.ФедянинМ. Ю.FedyaninM. Yu.fedianinmu@mail.ruИгнатоваЕ. О.IgnatovaE. O.

аспирант отделения клинической фармакологии и химиотерапии

md.ignatova@gmail.ruТюляндинС. А.TyulyandinS. A.

д.м.н., профессор, заведующий отделением клинической фармакологии и химиотерапии

stjulandin@gmail.comФГБУ Российский онкологический научный центр им. Ак. Н.Н. Блохина РАМНRussian Federation20132005201501314Copyright © Федянин М.Ю., Игнатова Е.О., Тюляндин С.А., 20152015Федянин М.Ю., Игнатова Е.О., Тюляндин С.А.Fedyanin M.Y., Ignatova E.O., Tyulyandin S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/17

Последнее десятилетие сопровождается появлением большого количества исследований, посвященных роли малых, не кодирующих белок, молекул РНК (микро-РНК) в канцерогенезе и развитии резистентности к проводимой противоопухолевой терапии. Семейство генов микро-РНК составляет немногим более 1% от всего генома человека, но регулирует экспрессию почти трети всех генов на посттранскрипционном уровне. При нарастающем внимании специалистов к персонализированному подходу в лечении онкологических больных, внедрение знаний по роли микро-РНК в клинику позволит в будущем индивидуализировать подход в лечении этого сложного контингента пациентов. В этом обзоре приводится информация о номенклатуре и механизмах образования микро-РНК, анализируется взаимосвязь между профилем экспрессии микро-РНК и фенотипом опухоли, а также обсуждается возможное применение микро-РНК в клинической практике.

Large number of studies on the role of small, non-coding the protein, RNA molecules (microRNAs) in carcinogenesis and the development of resistance to anticancer therapy published in last decade. The family of micro-RNA genes constitutes a little over 1% of the human genome, but regulates the expression of almost a third of all genes in the post-transcriptional level. With the rising attention of specialists to the personalized approach in the treatment of cancer patients, the introduction of knowledge on the role of miRNAs in the clinic in the future will allow to individualize the approach to the treatment of this complex patient population. This review provides information on the range and mechanisms of formation of micro-RNAs, analyzes the relationship between the expression profile of miRNAs and the phenotype of the tumor, as well as discusses the possible using of micro-RNAs in clinical practice.

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The authors declare that there are no conflicts of interest present.