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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">tumors-159</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Генетическая гетерогенность меланомы кожи: новые мишени для селективного воздействия</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазуренко</surname><given-names>Наталья Николаевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.б.н., профессор, зав. лаборатории онкогеномики,</p><p>г. Москва</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ «Российский онкологический научный центр им. Н.Н.Блохина»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>21</day><month>11</month><year>2015</year></pub-date><volume>0</volume><issue>4s2</issue><fpage>3</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мазуренко Н.Н., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Мазуренко Н.Н.</copyright-holder><copyright-holder xml:lang="en">Мазуренко Н.Н.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/159">https://www.malignanttumors.org/jour/article/view/159</self-uri><abstract><p>В последнее время достигнуты значительные успехи в понимании молекулярных механизмов возникновения и развитии меланомы и наметился реальный прогресс в лечении пациентов с метастатической меланомой. Улучшение результатов послеоперационного лечения стало возможно благодаря блокаде основных сигнальных путей, специфичных для меланомы, с использованием молекулярно-нацеленных, таргетных, препаратов, ингибирующих продукты онкогенов.</p></abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мазуренко Н. Н. Генетические особенности и маркеры меланомы кожи. Усп. мол. онкологии. 2014; 1(2): 27–36.</mixed-citation><mixed-citation xml:lang="en">Мазуренко Н. Н. Генетические особенности и маркеры меланомы кожи. Усп. мол. онкологии. 2014; 1(2): 27–36.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Мазуренко Н. Н., И. В. Цыганова, А. А. Лушникова и др. Спектр мутаций онкогенов различается в субтипах меланомы кожи. Мол. биол. 2015; 49(6).</mixed-citation><mixed-citation xml:lang="en">Мазуренко Н. Н., И. В. 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