tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2015-4-52-61tumors-158Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSМеханизмы развития и пути преодоления эндокринной резистентности при раке молочной железыMechanisms of development and the ways to overcome endocrine resistance in breast cancerХисамовАртур АльбертовичKhisamovArtur Albertovich

врач-хирург,

г. Москва

general surgeon

a.khisamov@mknc.ruМануйловаОльга ОлеговнаManujlovaOlga Olegovna

зам. заведующего Клиники женского здоровья,

г. Москва

Deputy Chief of Woman’s Health Clinic

БяховМихаил ЮрьевичByakhovMikhail Yuryevich

д.м.н., профессор, зам. директора по онкологии,

г. Москва

MD, PhD, DSc, Professor, Deputy Director

ГБУЗ МКНЦ ДЗМРоссияMoscow Clinical Scientific CenterRussian FederationГБУЗ МКНЦ ДЗМРоссияMoscow Clinical Scientific Center for OncologyRussian Federation201521112015045261Copyright © Хисамов А.А., Мануйлова О.О., Бяхов М.Ю., 20152015Хисамов А.А., Мануйлова О.О., Бяхов М.Ю.Khisamov A.A., Manujlova O.O., Byakhov M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/158

Около 70% случаев рака молочной железы (РМЖ) представляют собой гормон-чувствительные опухоли, и основным методом лечения таких опухолей является антиэстрогеновая терапия. На данный момент времени, существенной проблемой остается развитие эндокринной резистентности при применении гормонального лечения. В статье приведен обзор литературы о сигнальных путях, регулирующих опухолевый рост, механизмах развития эндокринной резистентности и о возможных путях ее преодоления.

About 70% of cases of breast cancer (BC) are hormone-dependent tumors and the main method of treatment of such patients is antiestrogen therapy. At this time, development of endocrine resistance during this type of treatment remains a significant problem. This article reviews literature on signal pathways that regulate tumor growth, mechanisms of development of endocrine resistance and possible ways to overcome it.

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The authors declare that there are no conflicts of interest present.