tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2015-4-14-23tumors-153Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSОпухолевое микроокружение как мишень терапии злокачественных глиомTumor microenvironment as a target of malignant gliomas treatmentБорисовКонстантин ЕвгеньевичBorisovKonstantin Evgen’evich

к.м.н., врач-онколог

MD, PhD, Oncologist

konstantin9671@rambler.ruСакаеваДина ДамировнаSakaevaDina Damirovna

д.м.н., зам. гл. врача по химиотерапии,

Уфа

MD, PhD, DSc, Deputy Chief Physician in chemotherapy,

 Ufa

d_sakaeva@mail.ruГУЗ Республиканский клинический онкологический диспансер Минздрава Республики БашкортостанРоссияRepublican Clinical Dispensary, Ministry of Health of the Republic of BashkortostanRussian FederationГУЗ Республиканский клинический онкологический диспансер Минздрава Республики БашкортостанРоссияRepublican Clinical Oncological Health Center of Republic of Bashkortostan Ministry of HealthRussian Federation201520112015041423Copyright © Борисов К.Е., Сакаева Д.Д., 20152015Борисов К.Е., Сакаева Д.Д.Borisov K.E., Sakaeva D.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/153

Клетки микроглии в злокачественных глиомах тесным образом взаимодействуют с опухолевыми клетками. Микроокружение обеспечивает локальную иммуносупрессию, которая способствует ускользанию опухоли от иммунного контроля со стороны организма. Многочисленные цитокины, секретируемые микроокружением обеспечивают выживание, питание, рост, пролиферацию и инвазию опухолевых клеток. Лечебное воздействие на микроокружение является не менее значимым, чем традиционная цитостатическая терапия. Перспективными представляются методы терапии, направленные на снижение рекрутинга иммунных клеток и их количества в ткани опухоли, на нейтрализацию иммуносупрессивных свойств микроглии и/или инверсию ее супрессивного фенотипа, а также на растормаживание и стимуляцию тумороцидных функций микроокружения.

Microglial cells in malignant gliomas closely interact with tumor cells. Microenvironment provides local immunosuppression, which promotes escape of tumors from immune system control. Numerous cytokines secreted by microenvironment support survival, nutrition, growth, proliferation and invasion of tumor cells. Microenvironment-targeted therapy is no less important than the traditional cytostatic therapy. Seem promising therapies aimed at reducing the recruitment of immune cells and their amounts in the tumor tissue, at neutralizationof the immunosuppressive properties of microglia and / or inversion of its suppressive phenotype, as well as disinhibition and stimulation of antineoplastic functions of microenvironment.

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The authors declare that there are no conflicts of interest present.