tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2025-051tumors-1495Research ArticleОБЗОРЫ И АНАЛИТИКАREVIEWS AND ANALYSISБиопсия сторожевых лимфатических узлов у больных раком молочной железы на фоне беременности. Литературный обзорSentinel Lymph Node Biopsy in Pregnant Breast Cancer Patients: A Literature Reviewhttps://orcid.org/0000-0003-1710-0772ПароконнаяА. А.ParokonnayaA. A.

Анастасия Анатольевна Пароконная  

115478 Москва, Каширское шоссе, 23 

Anastasiya Anatolevna Parokonnaya 

23 Kashirskoe Shosse, Moscow 115478

anapar1@yandex.ruhttps://orcid.org/0000-0002-8476-7879КрыловА. С.KrylovA. S.

Крылов Александр Сергеевич 

115478 Москва, Каширское шоссе, 23 

Krylov Alexander Sergeevich

23 Kashirskoe Shosse, Moscow 115478

https://orcid.org/0000-0002-2206-1002ШмаковР. Г.ShmakovR. G.

Шмаков Роман Георгиевич 

101000 Москва, ул. Покровка, 22-а 

Shmakov Roman Georgievich

22a Pokrovka St., Moscow 101000

https://orcid.org/0000-0002-7514-280XПетровскийА. В.PetrovskiiA. V.

Петровский Александр Валерьевич 

115478 Москва, Каширское шоссе, 23 

Petrovsky Alexander Valerievich

23 Kashirskoe Shosse, Moscow 115478

ФГБУ «Научный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииРоссияN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaRussian FederationМосковский областной НИИ акушерства и гинекологии им. академика В. И. КраснопольскогоРоссияMoscow Regional Research Institute of Obstetrics and Gynecology named after Academician V. I. KrasnopolskyRussian Federation2025301020251535360Copyright © Пароконная А.А., Крылов А.С., Шмаков Р.Г., Петровский А.В., 20252025Пароконная А.А., Крылов А.С., Шмаков Р.Г., Петровский А.В.Parokonnaya A.A., Krylov A.S., Shmakov R.G., Petrovskii A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/1495

Данный литературный обзор анализирует современные подходы к ведению беременных пациенток с диагностированным раком молочной железы (РМЖ) с использованием биопсии сторожевого лимфатического узла (БСЛУ). БСЛУ представляет собой безопасную альтернативу диссекции аксиллярных лимфоузлов при клинически «негативных» лимфатических узлах, значительно снижая нежелательные последствия хирургического лечения, такие как лимфедема и ограничение подвижности. В обзоре приводятся последние данные по использованию радионуклидного картирования лимфатических узлов с 99mTc (в дозах ≤ 10 МБк). Приводятся данные, подтверждающие безопасность метода для плода, отсутствие повышенного риска врожденных аномалий или осложнений беременности. Метод, помимо безопасности, сравним по эффективности и сопоставим по результатам с группой небеременных пациенток. В обзоре рассматриваются современные клинические рекомендации по лечению беременных пациенток, которые в целом поддерживают использование данного метода, рекомендуя индивидуальный подход. Критическое значение приобретает мультидисциплинарная тактика с участием онкологов, хирургов и акушеров-гинекологов для баланса между эффективностью лечения матери и безопасностью плода. Для включения в настоящий обзор были отобраны статьи, изучающие безопасность и эффективность БСЛУ у беременных пациенток с использованием баз данных MEDLINE, Goo UpToDate, Web of Science, Scopus.

This literature review analyzes current approaches to the management of pregnant patients with breast cancer (BC) using sentinel lymph node biopsy (SLNB). SLNB represents a safe alternative to axillary lymph node dissection (ALND) in clinically node-negative patients, significantly reducing adverse surgical sequelae such as lymphedema and restricted mobility. The review presents the latest data on the use of radionuclide lymph node mapping with 99mTc (in doses ≤ 10 MBq). Data confirming the safety of the procedure for the fetus, including the absence of an increased risk of congenital anomalies or pregnancy complications, are provided. The method, besides being safe, is comparable in effectiveness and outcomes to the non-pregnant patient group. The review discusses current clinical guidelines for treating pregnant patients, which generally support the use of this approach, recommending an individualized strategy. Multidisciplinary management involving oncologists, surgeons, and obstetrician-gynecologists is critically important to balance maternal treatment efficacy with fetal safety. Articles investigating the safety and efficacy of SLNB in pregnant patients were selected for inclusion in this review using the MEDLINE, UpToDate, Web of Science, and Scopus databases.

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The authors declare that there are no conflicts of interest present.