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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18027/2224-5057-2015-3-24-33</article-id><article-id custom-type="elpub" pub-id-type="custom">tumors-149</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group></article-categories><title-group><article-title>Современное состояние проблемы лечения резистентного к радиоактивному йоду дифференицированного рака щитовидной железы и клинический случай длительного успешного лечения сорафенибом</article-title><trans-title-group xml:lang="en"><trans-title>Current status of differetiated radioactive iodine-resistant thyroid cancer: case report of successful long-term treatment with sorafenib</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>МУФАЗАЛОВ</surname><given-names>Ф. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>MUFAZALOV</surname><given-names>F. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м.н., профессор,заместитель главного врача</p></bio><bio xml:lang="en"><p>doctor of medical sciences, professor, RCOHC deputy chief physician, chief radiologist</p></bio><email xlink:type="simple">prffm@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ШАРИПОВА</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>SHARIPOVA</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-радиотерапевт</p></bio><bio xml:lang="en"><p>MD, radiologist</p></bio><email xlink:type="simple">sh-nailya27@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Республиканский клинический онкологический диспансер» МЗ республики Башкортостан по радиологии, главный радиолог МЗ Республики Башкортостан</institution><country>Россия</country></aff><aff xml:lang="en"><institution>GBUZ “Republican clinical oncological health center (RCOHC)” Bashkortostan Republic Ministry of Healthcare</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>отделение радиологии № 2 ГБУЗ «Республиканский клинический онкологический диспансер» МЗ республики Башкортостан</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Radiology No. 2 in GBUZ “Republican clinical oncological health center (RCOHC)” Bashkortostan Republic Ministry of Healthcare</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>26</day><month>10</month><year>2015</year></pub-date><volume>0</volume><issue>3</issue><fpage>24</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; МУФАЗАЛОВ Ф.Ф., ШАРИПОВА Н.С., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">МУФАЗАЛОВ Ф.Ф., ШАРИПОВА Н.С.</copyright-holder><copyright-holder xml:lang="en">MUFAZALOV F.F., SHARIPOVA N.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/149">https://www.malignanttumors.org/jour/article/view/149</self-uri><abstract><p>Рак щитовидной железы (РЩЖ) является наиболее распространенным эндокринным злокачественным новообразованием. За последнее десятилетие заболеваемость РЩЖ в мире и в Российской Федерации (РФ) неуклонно растет [1, 2]. Так, в Соединенных Штатах Америки отмечается ежегодный прирост выявленных случаев РЩЖ на 6,4%, с частотой прироста смертности в среднем на 0,9% [<xref ref-type="bibr" rid="cit3">3</xref>]. В РФ в период с 2003–2013 гг. численность контингента больных РЩЖ возрастает из года в год в среднем на 5,4%. В 2013 г. в РФ выявлено 9624 новых случаев РЩЖ, численность контингента больных на 100 000 населения составила 93,2 [<xref ref-type="bibr" rid="cit1">1</xref>]. Дифференцированный рак щитовидной железы (ДРЩЖ) составляет более 90% всех типов РЩЖ [<xref ref-type="bibr" rid="cit4">4</xref>].</p></abstract><trans-abstract xml:lang="en"><p>Thyroid cancer is one of the most widespreaded malignant endocrine tumors. Morbidity is constantly increasing in the world and in Russian Federation during last decade [1, 2]. So, in the United States marked annual increase of diagnosed cases of thyroid cancer by 6.4% with increasing of mortality by 0.9% [<xref ref-type="bibr" rid="cit3">3</xref>]. In Russian Federation marked annual increase of diagnosed cases by 5.4% in 2003–2013. In 2013 in Russian Federation diagnosed 9624 new cases of thyroid cancer with morbidity 93.2 on 100 000 citizens [<xref ref-type="bibr" rid="cit1">1</xref>]. Differentiated thyroid cancer is more than 90% of all cases of thyroid cancer [<xref ref-type="bibr" rid="cit4">4</xref>].</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дифференцированный рак щитовидной железы</kwd><kwd>резистентный к радиоактивному йоду</kwd><kwd>сорафениб</kwd><kwd>ленватиниб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>radioactive iodine-resistant differentiated thyroid cancer</kwd><kwd>sorafenib</kwd><kwd>lenvatinib</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">А. Д. Каприн, В. В. Старинский, Г. В. Петрова. Состояние онкологической помощи населению России в 2012 году. М. –2013. Kaprin A. D., Starinskiy V. V., Petrova G. V. Current status of oncological healthcare in Russia in 2012. M. –2013.</mixed-citation><mixed-citation xml:lang="en">А. Д. Каприн, В. В. Старинский, Г. В. Петрова. Состояние онкологической помощи населению России в 2012 году. М. –2013. Kaprin A. D., Starinskiy V. V., Petrova G. V. Current status of oncological healthcare in Russia in 2012. M. –2013.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Pellegriti, G., Frasca, F., Regalbuto, C., Squatrito, S. and Vigneri, R. (2013) Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol 2013: 965212.</mixed-citation><mixed-citation xml:lang="en">Pellegriti, G., Frasca, F., Regalbuto, C., Squatrito, S. and Vigneri, R. (2013) Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol 2013: 965212.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">National Cancer Institute Surveillance, Epidemiology, and End Results program (NCI SEER) stat fact sheet: http://seer.cancer.gov/statfacts/html/thyro.html</mixed-citation><mixed-citation xml:lang="en">National Cancer Institute Surveillance, Epidemiology, and End Results program (NCI SEER) stat fact sheet: http://seer.cancer.gov/statfacts/html/thyro.html</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">NCI SEER cancer statistics review: http://seer.cancer.gov/csr/1975_2010/results_merged/sect_26_thyroid.pdf</mixed-citation><mixed-citation xml:lang="en">NCI SEER cancer statistics review: http://seer.cancer.gov/csr/1975_2010/results_merged/sect_26_thyroid.pdf</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">NCCN (2014) NCCN Clinical Practice Guidelines in Oncology. Cancer-related Fatigue (version 1.2014). Fort Washington, PA: National Comprehensive Cancer Network.</mixed-citation><mixed-citation xml:lang="en">NCCN (2014) NCCN Clinical Practice Guidelines in Oncology. Cancer-related Fatigue (version 1.2014). Fort Washington, PA: National Comprehensive Cancer Network.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cooper, D., Doherty, G., Haugen, B., Kloos, R. and Al., E. (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19: 1167–1214.</mixed-citation><mixed-citation xml:lang="en">Cooper, D., Doherty, G., Haugen, B., Kloos, R. and Al., E. (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19: 1167–1214.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hundahl, S., Fleming, I., Fremgen, A. and Menck, H. (1998) A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995 [see comments]. Cancer 83: 2638–2648.</mixed-citation><mixed-citation xml:lang="en">Hundahl, S., Fleming, I., Fremgen, A. and Menck, H. (1998) A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995 [see comments]. Cancer 83: 2638–2648.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sciuto, R., Romano, L., Rea, S., Marandino, F., Sperduti, I. and Maini, C. (2009) Natural history and clinical outcome of differentiated thyroid carcinoma: a retrospective analysis of 1503 patients treated at a single institution. Ann Oncol 20: 1728–1735.</mixed-citation><mixed-citation xml:lang="en">Sciuto, R., Romano, L., Rea, S., Marandino, F., Sperduti, I. and Maini, C. (2009) Natural history and clinical outcome of differentiated thyroid carcinoma: a retrospective analysis of 1503 patients treated at a single institution. Ann Oncol 20: 1728–1735.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Pacini, F. and Castagna, M. (2012) Approach to and treatment of differentiated thyroid carcinoma. Med Clin North Am 96: 369–383.</mixed-citation><mixed-citation xml:lang="en">Pacini, F. and Castagna, M. (2012) Approach to and treatment of differentiated thyroid carcinoma. Med Clin North Am 96: 369–383.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Xing, M., Haugen, B. and Schlumberger, M. (2013) Progress in molecular-based management of differentiated thyroid cancer. Lancet 381: 1058–1069.</mixed-citation><mixed-citation xml:lang="en">Xing, M., Haugen, B. and Schlumberger, M. (2013) Progress in molecular-based management of differentiated thyroid cancer. Lancet 381: 1058–1069.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Amin, A., Badwey, A. and El-Fatah, S. (2014) Differentiated thyroid carcinoma: an analysis of 249 patients undergoing therapy and aftercare at a single institution. Clin Nucl Med 39: 142–146.</mixed-citation><mixed-citation xml:lang="en">Amin, A., Badwey, A. and El-Fatah, S. (2014) Differentiated thyroid carcinoma: an analysis of 249 patients undergoing therapy and aftercare at a single institution. Clin Nucl Med 39: 142–146.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Nixon, I., Whitcher, M., Palmer, F., Tuttle, R., Shaha, A., Shah, J. et al. (2012) The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland. Thyroid 22: 884–889.</mixed-citation><mixed-citation xml:lang="en">Nixon, I., Whitcher, M., Palmer, F., Tuttle, R., Shaha, A., Shah, J. et al. (2012) The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland. Thyroid 22: 884–889.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Durante, C., Haddy, N., Baudin, E., Leboulleux, S., Hartl, D., Travagli, J. et al. (2006) Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 91: 2892–2899.</mixed-citation><mixed-citation xml:lang="en">Durante, C., Haddy, N., Baudin, E., Leboulleux, S., Hartl, D., Travagli, J. et al. (2006) Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 91: 2892–2899.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Robbins, R., Wan, Q., Grewal, R., Reibke, R., Gonen, M., Strauss, H. et al. (2006) Real-time prognosis for metastatic thyroid carcinoma based on 2-[18f] fluoro-2-deoxy-d-glucose-positron emission tomography scanning. J Clin Endocrinol Metab 91: 498–505.</mixed-citation><mixed-citation xml:lang="en">Robbins, R., Wan, Q., Grewal, R., Reibke, R., Gonen, M., Strauss, H. et al. (2006) Real-time prognosis for metastatic thyroid carcinoma based on 2-[18f] fluoro-2-deoxy-d-glucose-positron emission tomography scanning. J Clin Endocrinol Metab 91: 498–505.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Shimaoka, K., Schoenfeld, D., Dewys, W., Creech, R. and Deconti, R. (1985) A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma. Cancer 56: 2155–2160.</mixed-citation><mixed-citation xml:lang="en">Shimaoka, K., Schoenfeld, D., Dewys, W., Creech, R. and Deconti, R. (1985) A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma. Cancer 56: 2155–2160.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Matuszczyk, A., Petersenn, S., Bockisch, A., Gorges, R., Sheu, S., Veit, P. et al. (2008) Chemotherapy with doxorubicin in progressive medullary and thyroid carcinoma of the follicular epithelium. Horm Metab Res 40: 210–213.</mixed-citation><mixed-citation xml:lang="en">Matuszczyk, A., Petersenn, S., Bockisch, A., Gorges, R., Sheu, S., Veit, P. et al. (2008) Chemotherapy with doxorubicin in progressive medullary and thyroid carcinoma of the follicular epithelium. Horm Metab Res 40: 210–213.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">NCCN (2013) NCCN Clinical Practice Guidelines in Oncology. Thyroid carcinoma (version 2.2013). Fort Washington, PA: National Comprehensive Cancer Network.</mixed-citation><mixed-citation xml:lang="en">NCCN (2013) NCCN Clinical Practice Guidelines in Oncology. Thyroid carcinoma (version 2.2013). Fort Washington, PA: National Comprehensive Cancer Network.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Spano JP, Vano Y, Vignot S, et al. GEMOX regimen in the treatmentof metastatic differentiated refractory thyroid carcinoma. Med Oncol 2012; 29:1421–8.</mixed-citation><mixed-citation xml:lang="en">Spano JP, Vano Y, Vignot S, et al. GEMOX regimen in the treatmentof metastatic differentiated refractory thyroid carcinoma. Med Oncol 2012; 29:1421–8.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman SI. Early clinical studies of novel therapies for thyroid can-cers. Endocrinol Metab Clin North Am 2008; 37:511–24, xi.</mixed-citation><mixed-citation xml:lang="en">Sherman SI. Early clinical studies of novel therapies for thyroid can-cers. Endocrinol Metab Clin North Am 2008; 37:511–24, xi.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">US Food and Drug Administration (2013) FDA news release: FDA approves nexavar to treat type of thyroid cancer. Silver Spring, MD.</mixed-citation><mixed-citation xml:lang="en">US Food and Drug Administration (2013) FDA news release: FDA approves nexavar to treat type of thyroid cancer. Silver Spring, MD.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">US Food and Drug Administration (2015) FDA news release: FDA approves Lenvima for a type of thyroid cancer.</mixed-citation><mixed-citation xml:lang="en">US Food and Drug Administration (2015) FDA news release: FDA approves Lenvima for a type of thyroid cancer.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Wilhelm, S., Adnane, L., Newell, P., Villanueva, A., Llovet, J. and Lynch, M. (2008) Preclinical overview of sorafenib, a multikinase inhibitor that targets bothRaf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7: 3129–3140.</mixed-citation><mixed-citation xml:lang="en">Wilhelm, S., Adnane, L., Newell, P., Villanueva, A., Llovet, J. and Lynch, M. (2008) Preclinical overview of sorafenib, a multikinase inhibitor that targets bothRaf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7: 3129–3140.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Matsui, J., Yamamoto, Y., Funahashi, Y., Tsuruoka, A., Watanabe, T., Wakabayashi, T. et al. (2008) E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 122: 664–671.</mixed-citation><mixed-citation xml:lang="en">Matsui, J., Yamamoto, Y., Funahashi, Y., Tsuruoka, A., Watanabe, T., Wakabayashi, T. et al. (2008) E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 122: 664–671.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Okamoto, K., Kodama, K., Takase, K., Sugi, N., Yamamoto, Y., Iwata, M. et al. (2013) Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (e7080) against ret gene fusion-driven tumor models. Cancer Lett 340: 97–103.</mixed-citation><mixed-citation xml:lang="en">Okamoto, K., Kodama, K., Takase, K., Sugi, N., Yamamoto, Y., Iwata, M. et al. (2013) Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (e7080) against ret gene fusion-driven tumor models. Cancer Lett 340: 97–103.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta-Abramson V, Troxel AB, Nellore A, et al. Phase II trialof sorafenib in advanced thyroid cancer. J Clin Oncol 2008; 26:4714–9.</mixed-citation><mixed-citation xml:lang="en">Gupta-Abramson V, Troxel AB, Nellore A, et al. Phase II trialof sorafenib in advanced thyroid cancer. J Clin Oncol 2008; 26:4714–9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kloos RT, Ringel MD, Knopp MV, et al. Phase II trial of sorafenib inmetastatic thyroid cancer. J Clin Oncol 2009; 27:1675–84.</mixed-citation><mixed-citation xml:lang="en">Kloos RT, Ringel MD, Knopp MV, et al. Phase II trial of sorafenib inmetastatic thyroid cancer. J Clin Oncol 2009; 27:1675–84.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Cabanillas ME, Waguespack SG, Bronstein Y, et al. Treatment withtyrosine kinase inhibitors for patients with differentiated thyroidcancer: the M D. Anderson experience. J Clin Endocrinol Metab 2010; 95:2588–95.</mixed-citation><mixed-citation xml:lang="en">Cabanillas ME, Waguespack SG, Bronstein Y, et al. Treatment withtyrosine kinase inhibitors for patients with differentiated thyroidcancer: the M D. Anderson experience. J Clin Endocrinol Metab 2010; 95:2588–95.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hoftijzer H, Heemstra KA, Morreau H, et al. Beneficial effectsof sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. Eur J Endocrinol 2009; 161:923–31.</mixed-citation><mixed-citation xml:lang="en">Hoftijzer H, Heemstra KA, Morreau H, et al. Beneficial effectsof sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. Eur J Endocrinol 2009; 161:923–31.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Marotta V, Ramundo V, Camera L, et al. Sorafenib in advancediodine-refractory differentiated thyroid cancer: efficacy, safety andexploratory analysis of role of serum thyroglobulin and FDG-PET.Clin Endocrinol (Oxf) 2012.</mixed-citation><mixed-citation xml:lang="en">Marotta V, Ramundo V, Camera L, et al. Sorafenib in advancediodine-refractory differentiated thyroid cancer: efficacy, safety andexploratory analysis of role of serum thyroglobulin and FDG-PET.Clin Endocrinol (Oxf) 2012.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Brose MS, Nutting CM, Jarzab B, et al. Sorafenib in radioac-tive iodine-refractory, locally advanced or metastatic differentiatedthyroid cancer: a randomised, double-blind, phase 3 trial. Lancet 2014.</mixed-citation><mixed-citation xml:lang="en">Brose MS, Nutting CM, Jarzab B, et al. Sorafenib in radioac-tive iodine-refractory, locally advanced or metastatic differentiatedthyroid cancer: a randomised, double-blind, phase 3 trial. Lancet 2014.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Brose MS, Nutting CM, Sherman SI, et al. Rationale and design of decision: a double-blind, randomized, placebo-controlled phase III trial evaluating the efficacy and safety of sorafenib in patients with locally advanced or metastatic radioactive iodine (RAI)- refractory, differentiated thyroid cancer. BMC Cancer. 2011; 11:349.</mixed-citation><mixed-citation xml:lang="en">Brose MS, Nutting CM, Sherman SI, et al. Rationale and design of decision: a double-blind, randomized, placebo-controlled phase III trial evaluating the efficacy and safety of sorafenib in patients with locally advanced or metastatic radioactive iodine (RAI)- refractory, differentiated thyroid cancer. BMC Cancer. 2011; 11:349.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Schlumberger, M., Tahara, M., Wirth, L., Robinson, B., Brose, M., Elisei, R. et al. (2014) A phase 3, multicenter, randomized, double-blind, placebocontrolled trial of lenvatinib (E7080) in patients with131-I-refractory differentiated thyroid cancer (SELECT) [Abstract LBA6008]. Paper presented at American Society of Clinical Oncology, Chicago, IL, 30 May-3 June 2013.</mixed-citation><mixed-citation xml:lang="en">Schlumberger, M., Tahara, M., Wirth, L., Robinson, B., Brose, M., Elisei, R. et al. (2014) A phase 3, multicenter, randomized, double-blind, placebocontrolled trial of lenvatinib (E7080) in patients with131-I-refractory differentiated thyroid cancer (SELECT) [Abstract LBA6008]. Paper presented at American Society of Clinical Oncology, Chicago, IL, 30 May-3 June 2013.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Eisai Inc. A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of lenvatinib (E7080) in 131I refractory differentiated thyroid cancer. http://clinicaltrials.gov/ct2/show/NCT01321554?term=lenvatinib+AND+thyroid+cancer&amp;r. Accessed July 2, 2013.</mixed-citation><mixed-citation xml:lang="en">Eisai Inc. A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of lenvatinib (E7080) in 131I refractory differentiated thyroid cancer. http://clinicaltrials.gov/ct2/show/NCT01321554?term=lenvatinib+AND+thyroid+cancer&amp;r. Accessed July 2, 2013.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman, E., Ho, A., Fury, M., Baxi, S., Haque, S., Lipson, B. et al. (2013) Phase II study of everolimus and sorafenib for the treatment of metastatic thyroid cancer. J Clin Oncol 31: 6024.</mixed-citation><mixed-citation xml:lang="en">Sherman, E., Ho, A., Fury, M., Baxi, S., Haque, S., Lipson, B. et al. (2013) Phase II study of everolimus and sorafenib for the treatment of metastatic thyroid cancer. J Clin Oncol 31: 6024.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman, E., Ho, A., Fury, M., Baxi, S., Haque, S., Korte, S. et al. (2012) A phase II study of temsirolimus/ sorafenib in patients with radioactive iodine (RAI)- refractory thyroid arcinoma. J Clin Oncol 30: 5514.</mixed-citation><mixed-citation xml:lang="en">Sherman, E., Ho, A., Fury, M., Baxi, S., Haque, S., Korte, S. et al. (2012) A phase II study of temsirolimus/ sorafenib in patients with radioactive iodine (RAI)- refractory thyroid arcinoma. J Clin Oncol 30: 5514.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ho, A., Grewal, R., Leboeuf, R., Sherman, E., Pfister, D., Deandreis, D. et al. (2013) Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. N Engl J Med 368: 623–632.</mixed-citation><mixed-citation xml:lang="en">Ho, A., Grewal, R., Leboeuf, R., Sherman, E., Pfister, D., Deandreis, D. et al. (2013) Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. N Engl J Med 368: 623–632.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">ClinicalTrials.gov identifier: NCT00970359.</mixed-citation><mixed-citation xml:lang="en">ClinicalTrials.gov identifier: NCT00970359.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sacks, W. and Braunstein, G. (2013) Evolving approaches in managing radioactive iodine-refractory differentiated thyroid cancer. Endocr Pract: 1–36.</mixed-citation><mixed-citation xml:lang="en">Sacks, W. and Braunstein, G. (2013) Evolving approaches in managing radioactive iodine-refractory differentiated thyroid cancer. Endocr Pract: 1–36.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">The resolution of the expert council for targeted therapy of radioiodine refractory differentiated thyroid cancer. ¦-§: ¨©ª«§¬ ®«§«¯° ¬ ±²¬ ³ 3, 2014, µ¶·.10–11.</mixed-citation><mixed-citation xml:lang="en">The resolution of the expert council for targeted therapy of radioiodine refractory differentiated thyroid cancer. ¦-§: ¨©ª«§¬ ®«§«¯° ¬ ±²¬ ³ 3, 2014, µ¶·.10–11.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Worden F. Treatment strategies for radioactive iodinerefractorydifferentiated thyroid cancer/ Ther Adv Med Oncol 2014, Vol. 6(6) 267–279 DOI: 10.1177/ 1758834014548188.</mixed-citation><mixed-citation xml:lang="en">Worden F. Treatment strategies for radioactive iodinerefractorydifferentiated thyroid cancer/ Ther Adv Med Oncol 2014, Vol. 6(6) 267–279 DOI: 10.1177/ 1758834014548188.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Schreinemakers, J., Vriens, M., Munoz-Perez, N., Guerrero, M., Suh, I., Rinkes, I. et al. (2012) Fluorodeoxyglucose-positron emission tomography scan-positive recurrent papillary thyroid cancer and the prognosis and implications for surgical management. World J Surg Oncol 10:192.</mixed-citation><mixed-citation xml:lang="en">Schreinemakers, J., Vriens, M., Munoz-Perez, N., Guerrero, M., Suh, I., Rinkes, I. et al. (2012) Fluorodeoxyglucose-positron emission tomography scan-positive recurrent papillary thyroid cancer and the prognosis and implications for surgical management. World J Surg Oncol 10:192.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Schlumberger, M., Brose, M., Elisei, R., Leboulleux, S., Luster, M., Pitoia, F. et al. (2014) Definition and management of radioactive iodine-refractory differentiated thyroid cancer. Lancet Diabetes Endocrinol 13:70215–70218.</mixed-citation><mixed-citation xml:lang="en">Schlumberger, M., Brose, M., Elisei, R., Leboulleux, S., Luster, M., Pitoia, F. et al. (2014) Definition and management of radioactive iodine-refractory differentiated thyroid cancer. Lancet Diabetes Endocrinol 13:70215–70218.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
