tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2025-046tumors-1474Research ArticleОБЗОРЫ И АНАЛИТИКАREVIEWS AND ANALYSISРоль неоадъювантной химиотерапии в лечении местнораспространенного рака шейки матки, или 40 лет хождения по доказательной пустынеThe role of neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer, or 40 years of walking in the evidence deserthttps://orcid.org/0009-0005-8135-5165ТанделовР. К.TandelovR. K.

Роман Казбекович Танделов

117997; ул. Академика Опарина, 4; Москва

Roman Kazbekovich Tandelov

117997; 4 Akademika Oparina St.; Moscow

r_tandelov@oparina4.ruhttps://orcid.org/0000-0001-9026-8331ПетрожицкаяА. А.PetrozhitskayaA. A.

Анна Александровна Петрожицкая

117997; ул. Академика Опарина, 4; Москва

Anna Aleksandrovna Petrozhitskaya

117997; 4 Akademika Oparina St.; Moscow

https://orcid.org/0000-0003-4768-115XСолоповаА. Е.SolopovaA. E.

Алина Евгеньевна Солопова

117997; ул. Академика Опарина, 4; Москва

Alina Evgenevna Solopova

117997; 4 Akademika Oparina St.; Moscow

https://orcid.org/0000-0001-7985-9050МорховК. Ю.MorkhovK. Yu.

Константин Юрьевич Морхов

117997; ул. Академика Опарина, 4; Москва

Konstantin Yurevich Morkhov

117997; 4 Akademika Oparina St.; Moscow

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В. И. Кулакова» Минздрава РоссииРоссияNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov” Ministry of Health of RussiaRussian Federation2025240820251524653Copyright © Танделов Р.К., Петрожицкая А.А., Солопова А.Е., Морхов К.Ю., 20252025Танделов Р.К., Петрожицкая А.А., Солопова А.Е., Морхов К.Ю.Tandelov R.K., Petrozhitskaya A.A., Solopova A.E., Morkhov K.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/1474

   Изучение роли неоадъювантной химиотерапии (НАХТ) началось с пионерских работ начала 1980‑х годов и продолжается уже более 40 лет. За это время проведено множество рандомизированных клинических исследований, выполнено немало скрупулёзных метаанализов, не раз были пересмотрены клинические рекомендации. Однако имеющиеся на данный момент результаты трудно назвать полностью удовлетворительными. После 40 лет хождения по пустыне доказательной медицины у нас нет твёрдых знаний о базовых вещах, есть ли место НАХТ в лечении рака шейки матки? Если да, то когда и кому её нужно назначать? Как быть, когда ответ опухоли на химиотерапию далек от удовлетворительного? Клиническое применение НАХТ остаётся во многом интуитивным, основанным на экстраполяции имеющихся знаний из других сфер онкологии. Авторы статьи смотрят на будущее НАХТ в лечении РШМ с осторожным оптимизмом и предлагают читателю вспомнить основные моменты исследования этого метода, чтобы попытаться понять, куда двигаться дальше.

   The study of the role of neoadjuvant chemotherapy (NACT) began with pioneering works in the early 1980s and has been ongoing for over 40 years. During this period, numerous randomized clinical trials have been conducted, many scrupulous meta-analyses have been performed, and clinical guidelines have been revised more than once. However, the results available at the moment can hardly be regarded as completely satisfying. After 40 years of walking in the desert of evidence-based medicine, we have no clear knowledge about the basic things: is there a place for NACT in the treatment of cervical cancer? If so, when and to whom should it be prescribed? What to do when the tumor response to chemotherapy is far from being satisfactory? The clinical application of NACT remains largely intuitive, based on extrapolation of available knowledge from other areas of oncology. The authors look at the future of NACT in the treatment of cervical cancer with cautious optimism, and invite the readers to recall the main points of the study of this method to help them understand where to go next.

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The authors declare that there are no conflicts of interest present.