<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18027/2224-5057-2025-036</article-id><article-id custom-type="elpub" pub-id-type="custom">tumors-1450</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОНСЕНСУС</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CONSENSUS</subject></subj-group></article-categories><title-group><article-title>Российский консенсус по профилактике, диагностике и лечению рака желудка. Вопросы лекарственной терапии</article-title><trans-title-group xml:lang="en"><trans-title>Russian consensus on prevention, diagnosis and treatment of gastric cancer. Systemic therapy issues</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7728-9533</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артамонова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Artamonova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Владимировна Артамонова </p><p>115478 Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Elena Vladimirovna Artamonova</p><p>23 Kashirskoe Shosse, Moscow 115478</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1693-0523</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бесова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Besova</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталия Сергеевна Бесова </p><p>115478 Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Nataliya Sergeevna Besova </p><p>23 Kashirskoe Shosse, Moscow 115478</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4879-2687</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Болотина</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bolotina</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Лариса Владимировна Болотина</p><p>125284 Москва, 2-й Боткинский пр-д, 3</p></bio><bio xml:lang="en"><p>Larisa Vladimirovna Bolotina </p><p>3 2nd Botkinskiy proezd, Moscow 125284</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4822-5044</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Владимирова</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Vladimirova</surname><given-names>L. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Любовь Юрьевна Владимирова </p><p>344037 Ростов-наДону, 14-я линия, 63</p></bio><bio xml:lang="en"><p>Lyubov Yurevna Vladimirova </p><p>63 14 liniya St., Rostov-on-Don 344037</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4848-6938</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жукова</surname><given-names>Л. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhukova</surname><given-names>L. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Людмила Григорьевна Жукова </p><p>111123 Москва, Новогиреевская ул., 1, корп. 1</p></bio><bio xml:lang="en"><p>Lyudmila Grigorevna Zhukova </p><p>Build. 1, 1 Novogireevskaya St., Moscow 111123</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8114-7885</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Игнатова</surname><given-names>Е. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Ignatova</surname><given-names>E. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Олеговна Игнатова </p><p>115478 Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Ekaterina Olegovna Ignatova </p><p>23 Kashirskoe Shosse, Moscow 115478</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9431-5617</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеенко</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseenko</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимир Михайлович Моисеенко </p><p>197758 Санкт-Петербург, пос. Песочный, Ленинградская ул., 68А, лит. А</p></bio><bio xml:lang="en"><p>Vladimir Mikhailovich Moiseenko </p><p>lit. A, 68A Leningradskaya St., Pesochnyy, Saint Petersburg 197758</p></bio><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9864-3837</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Покатаев</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pokataev</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Илья Анатольевич Покатаев </p><p>115478 Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Ilya Anatolevich Pokataev </p><p>23 Kashirskoe Shosse, Moscow 115478</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5543-199X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенов</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenov</surname><given-names>N. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николай Евгеньевич Семенов </p><p>111123 Москва, Новогиреевская ул., 1, корп. 1</p></bio><bio xml:lang="en"><p>Nikolai Evgenevich Semenov </p><p>Build. 1, 1 Novogireevskaya St., Moscow 111123</p></bio><email xlink:type="simple">n.semenov@mknc.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1973-1092</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Строяковский</surname><given-names>Д. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Stroyakovskii</surname><given-names>D. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Даниил Львович Строяковский </p><p>143515 Московская область, п. Истра, 27</p></bio><bio xml:lang="en"><p>Daniil Lvovich Stroyakovskii </p><p>27 Istra, Moscow Region 143515</p></bio><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2245-214X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трякин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tryakin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Александрович Трякин </p><p>115478 Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Aleksei Aleksandrovich Tryakin </p><p>23 Kashirskoe Shosse, Moscow 115478</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9807-2229</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тюляндин</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyulyandin</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергей Алексеевич Тюляндин </p><p>115478 Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Sergei Alekseevich Tyulyandin </p><p>23 Kashirskoe Shosse, Moscow 115478</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4927-5585</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Феденко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Александрович Феденко </p><p>125284 Москва, 2-й Боткинский пр-д, 3</p></bio><bio xml:lang="en"><p>Aleksandr Aleksandrovich Fedenko </p><p>3 2nd Botkinskiy proezd, Moscow 125284</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5615-7806</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федянин</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedyanin</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Михаил Юрьевич Федянин</p><p>115478 Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Mikhail Yurevich Fedyanin </p><p>23 Kashirskoe Shosse, Moscow 115478</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4533-1658</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шевкунов</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shevkunov</surname><given-names>L. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лев Николаевич Шевкунов </p><p>197758 Санкт-Петербург, п. Песочный, ул. Ленинградская, 68</p></bio><bio xml:lang="en"><p>Lev Nikolaevich Shevkunov </p><p>68 Leningradskaya St., Pesochnyy, Saint Petersburg 197758</p></bio><xref ref-type="aff" rid="aff-9"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia;</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Московский научно-исследовательский онкологический институт им. П.А. Герцена — филиал ФГБУ «Национальный&#13;
медицинский исследовательский центр радиологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P. A. Hertsen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Center, Ministry of Health&#13;
of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Centre for Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ГБУЗ г. Москвы «Московский клинический научно-практический центр им. А.С. Логинова Департамента здравоохранения г.&#13;
Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A. S. Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>БУЗ «Санкт-Петербургский клинический научно-практический центр специализированных видов медицинской помощи&#13;
(онкологический) им. Н.П. Напалкова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. P. Napalkov Saint Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>ГБУЗ г. Москвы «Московский клинический научно-практический центр им. А.С. Логинова Департамента здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A. S. Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>ГБУЗ г. Москвы «Московская городская онкологическая больница No 62 Департамента здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow City Oncology Hospital No. 62, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-9"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>15</day><month>04</month><year>2025</year></pub-date><volume>15</volume><issue>1</issue><elocation-id>76–85</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Артамонова Е.В., Бесова Н.С., Болотина Л.В., Владимирова Л.Ю., Жукова Л.Г., Игнатова Е.О., Моисеенко В.М., Покатаев И.А., Семенов Н.Е., Строяковский Д.Л., Трякин А.А., Тюляндин С.А., Феденко А.А., Федянин М.Ю., Шевкунов Л.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Артамонова Е.В., Бесова Н.С., Болотина Л.В., Владимирова Л.Ю., Жукова Л.Г., Игнатова Е.О., Моисеенко В.М., Покатаев И.А., Семенов Н.Е., Строяковский Д.Л., Трякин А.А., Тюляндин С.А., Феденко А.А., Федянин М.Ю., Шевкунов Л.Н.</copyright-holder><copyright-holder xml:lang="en">Artamonova E.V., Besova N.S., Bolotina L.V., Vladimirova L.Y., Zhukova L.G., Ignatova E.O., Moiseenko V.M., Pokataev I.A., Semenov N.E., Stroyakovskii D.L., Tryakin A.A., Tyulyandin S.A., Fedenko A.A., Fedyanin M.Y., Shevkunov L.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/1450">https://www.malignanttumors.org/jour/article/view/1450</self-uri><abstract><p>Российский консенсус по профилактике, диагностике и лечению рака желудка подготовлен по инициативе Московского клинического научного центра им А. С. Логинова ДЗМ по Дельфийской системе. Его целью явилась консолидация мнений отечественных специалистов по наиболее актуальным вопросам профилактики, скрининга, диагностики и лечения рака желудка. Междисциплинарный подход обеспечен участием ведущих гастроэнтерологов, онкологов и хирургов. В данной статье представлены ключевые нерешенные вопросы лекарственного лечения рака желудка, а также позиции Российского консенсуса по ним.</p></abstract><trans-abstract xml:lang="en"><p>The Russian consensus on prevention, diagnostic and treatment of gastric cancer was prepared on the initiative of the Moscow clinical scientific center named after A. S. Loginov on the Delphi method. Its aim was to clarify and consolidate the opinions of specialists on the most relevant issues of prevention, diagnosis and treatment of gastric cancer. An interdisciplinary approach was provided by the participation of leading gastroenterologists, oncologists and surgeons.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>консенсус</kwd><kwd>рак желудка</kwd><kwd>лекарственное лечение рака желудка</kwd><kwd>системная химиотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>consensus</kwd><kwd>gastric cancer</kwd><kwd>systemic therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Smyth E.C., Verheij M., Allum W., et al. ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2016;27(suppl 5):v38-v49. https://doi.org/10.1093/annonc/mdw350</mixed-citation><mixed-citation xml:lang="en">Smyth E.C., Verheij M., Allum W., et al. ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2016;27(suppl 5):v38-v49. https://doi.org/10.1093/annonc/mdw350</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer 2021;24(1):1–21. https://doi.org/10.1007/s10120-020-01041-y</mixed-citation><mixed-citation xml:lang="en">Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer 2021;24(1):1–21. https://doi.org/10.1007/s10120-020-01041-y</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">NCCN Clinical Practice Guideline for Gastric Cancer version 3.2020. https://www.nccn.org/professionals/physician_gls/pdf/gastric.pdf</mixed-citation><mixed-citation xml:lang="en">NCCN Clinical Practice Guideline for Gastric Cancer version 3.2020. https://www.nccn.org/professionals/physician_gls/pdf/gastric.pdf</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Guideline Committee of the Korean Gastric Cancer Association (KGCA), Development Working Group &amp; Review Panel. Korean Practice Guideline for Gastric Cancer 2018: an Evidence-based, Multi-disciplinary Approach. J Gastric Cancer 2019;19(1):1–48. doi: 10.5230/jgc.2019.19.e8. Epub 2019 Mar 19. Erratum in: J Gastric Cancer 2019 Sep;19(3):372–373</mixed-citation><mixed-citation xml:lang="en">Guideline Committee of the Korean Gastric Cancer Association (KGCA), Development Working Group &amp; Review Panel. Korean Practice Guideline for Gastric Cancer 2018: an Evidence-based, Multi-disciplinary Approach. J Gastric Cancer 2019;19(1):1–48. doi: 10.5230/jgc.2019.19.e8. Epub 2019 Mar 19. Erratum in: J Gastric Cancer 2019 Sep;19(3):372–373</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Polom K., Marano L., Marrelli D., et al. Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer. Br J Surg 2018;105(3):159–167. https://doi.org/10.1002/bjs.10663</mixed-citation><mixed-citation xml:lang="en">Polom K., Marano L., Marrelli D., et al. Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer. Br J Surg 2018;105(3):159–167. https://doi.org/10.1002/bjs.10663</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kim S.Y., Choi Y.Y., An J.Y., et al. The benefit of microsatellite instability is attenuated by chemotherapy in stage II and stage III gastric cancer: Results from a large cohort with subgroup analyses. Int J Cancer 2015;137(4):819–25. https://doi.org/10.1002/ijc.29449</mixed-citation><mixed-citation xml:lang="en">Kim S.Y., Choi Y.Y., An J.Y., et al. The benefit of microsatellite instability is attenuated by chemotherapy in stage II and stage III gastric cancer: Results from a large cohort with subgroup analyses. Int J Cancer 2015;137(4):819–25. https://doi.org/10.1002/ijc.29449</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Pietrantonio F., Miceli R., Raimondi A., et al. Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer. J Clin Oncol 2019;37(35):3392–3400. https://doi.org/10.1200/JCO.19.01124</mixed-citation><mixed-citation xml:lang="en">Pietrantonio F., Miceli R., Raimondi A., et al. Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer. J Clin Oncol 2019;37(35):3392–3400. https://doi.org/10.1200/JCO.19.01124</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">André T., Tougeron D., Piessen G., et al. Neoadjuvant nivolumab plus ipilimumab and adjuvant nivolumab in localized deficient mismatch repair/microsatellite instability-high gastric or esophagogastric junction adenocarcinoma: the GERCOR NEONIPIGA phase II study. J Clin Oncol 2023;41(2):255–265. https://doi.org/10.1200/JCO.22.00686</mixed-citation><mixed-citation xml:lang="en">André T., Tougeron D., Piessen G., et al. Neoadjuvant nivolumab plus ipilimumab and adjuvant nivolumab in localized deficient mismatch repair/microsatellite instability-high gastric or esophagogastric junction adenocarcinoma: the GERCOR NEONIPIGA phase II study. J Clin Oncol 2023;41(2):255–265. https://doi.org/10.1200/JCO.22.00686</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Pietrantonio F., Raimondi A., Lonardi S., et al. INFINITY: A multicentre, single-arm, multi-cohort, phase II trial of tremelimumab and durvalumab as neoadjuvant treatment of patients with microsatellite instability-high (MSI) resectable gastric or gastroesophageal junction adenocarcinoma (GAC/GEJAC). J Clin Oncol 2023;41(4): suppl 358. https://doi.org/10.1200/JCO.2023.41.4_suppl.358</mixed-citation><mixed-citation xml:lang="en">Pietrantonio F., Raimondi A., Lonardi S., et al. INFINITY: A multicentre, single-arm, multi-cohort, phase II trial of tremelimumab and durvalumab as neoadjuvant treatment of patients with microsatellite instability-high (MSI) resectable gastric or gastroesophageal junction adenocarcinoma (GAC/GEJAC). J Clin Oncol 2023;41(4): suppl 358. https://doi.org/10.1200/JCO.2023.41.4_suppl.358</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lorenzen S., Götze T.O., Thuss-Patience P., et al. Perioperative atezolizumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable esophagogastric cancer: interim results from the randomized, multicenter, phase II/III DANTE/IKF-s633 trial. J Clin Oncol 2024;42(4):410–420. https://doi.org/10.1200/JCO.23.00975</mixed-citation><mixed-citation xml:lang="en">Lorenzen S., Götze T.O., Thuss-Patience P., et al. Perioperative atezolizumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable esophagogastric cancer: interim results from the randomized, multicenter, phase II/III DANTE/IKF-s633 trial. J Clin Oncol 2024;42(4):410–420. https://doi.org/10.1200/JCO.23.00975</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sun H., Moiseyenko V., Chubenko V., et al. Neoadjuvant chemo-immunotherapy in mismatch repair deficient (dMMR)/ microsatellite instability (MSI) gastric carcinoma (GC): A multicenter retrospective study. Ann Oncol 2024;35(suppl_2):S180-S181. https://doi.org/10.1016/j.annonc.2024.05.362</mixed-citation><mixed-citation xml:lang="en">Sun H., Moiseyenko V., Chubenko V., et al. Neoadjuvant chemo-immunotherapy in mismatch repair deficient (dMMR)/ microsatellite instability (MSI) gastric carcinoma (GC): A multicenter retrospective study. Ann Oncol 2024;35(suppl_2):S180-S181. https://doi.org/10.1016/j.annonc.2024.05.362</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Van Cutsem E., Moiseyenko V.M., Tjulandin S., et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol 2006;24(31):4991–7. https://doi.org/10.1200/JCO.2006.06.8429</mixed-citation><mixed-citation xml:lang="en">Van Cutsem E., Moiseyenko V.M., Tjulandin S., et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol 2006;24(31):4991–7. https://doi.org/10.1200/JCO.2006.06.8429</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Wang J., Xu R., Li J., et al. Randomized multicenter phase III study of a modified docetaxel and cisplatin plus fluorouracil regimen compared with cisplatin and fluorouracil as first-line therapy for advanced or locally recurrent gastric cancer. Gastric Cancer 2016;19(1):234–44. https://doi.org/10.1007/s10120-015-0457-4</mixed-citation><mixed-citation xml:lang="en">Wang J., Xu R., Li J., et al. Randomized multicenter phase III study of a modified docetaxel and cisplatin plus fluorouracil regimen compared with cisplatin and fluorouracil as first-line therapy for advanced or locally recurrent gastric cancer. Gastric Cancer 2016;19(1):234–44. https://doi.org/10.1007/s10120-015-0457-4</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada Y., Boku N., Mizusawa J., et al. Docetaxel plus cisplatin and S-1 versus cisplatin and S-1 in patients with advanced gastric cancer (JCOG1013): an open-label, phase 3, randomised controlled trial. Lancet Gastroenterol Hepatol 2019;4(7):501–510. https://doi.org/10.1016/S2468-1253(19)30083-4</mixed-citation><mixed-citation xml:lang="en">Yamada Y., Boku N., Mizusawa J., et al. Docetaxel plus cisplatin and S-1 versus cisplatin and S-1 in patients with advanced gastric cancer (JCOG1013): an open-label, phase 3, randomised controlled trial. Lancet Gastroenterol Hepatol 2019;4(7):501–510. https://doi.org/10.1016/S2468-1253(19)30083-4</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Guo X., Zhao F., Ma X., et al. A comparison between triplet and doublet chemotherapy in improving the survival of patients with advanced gastric cancer: a systematic review and meta-analysis. BMC Cancer 2019;19(1):1125. https://doi.org/10.1186/s12885-019-6294-9</mixed-citation><mixed-citation xml:lang="en">Guo X., Zhao F., Ma X., et al. A comparison between triplet and doublet chemotherapy in improving the survival of patients with advanced gastric cancer: a systematic review and meta-analysis. BMC Cancer 2019;19(1):1125. https://doi.org/10.1186/s12885-019-6294-9</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zaanan A., Bouche O., de la Fouchardiere C., et al. LBA77 5-fluorouracil and oxaliplatin with or without docetaxel in the first-line treatment of HER2 negative locally advanced (LA) unresectable or metastatic gastric or gastro-esophageal junction (GEJ) adenocarcinoma (GASTFOX-PRODIGE 51): A randomized phase III trial sponsored by the FFCD. Ann Oncol 2023;34(suppl_2):S1254-S1335. https://doi.org/10.1016/S0923-7534(23)04149-2</mixed-citation><mixed-citation xml:lang="en">Zaanan A., Bouche O., de la Fouchardiere C., et al. LBA77 5-fluorouracil and oxaliplatin with or without docetaxel in the first-line treatment of HER2 negative locally advanced (LA) unresectable or metastatic gastric or gastro-esophageal junction (GEJ) adenocarcinoma (GASTFOX-PRODIGE 51): A randomized phase III trial sponsored by the FFCD. Ann Oncol 2023;34(suppl_2):S1254-S1335. https://doi.org/10.1016/S0923-7534(23)04149-2</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ramaswamy A., Bhargava P., Dubashi B., et al. A two-arm randomized open-label prospective design superiority phase III clinical trial to compare the efficacy of docetaxel-oxaliplatin-capecitabine/5 fluorouracil (DOC/F) followed by docetaxel versus CAPOX/mFOLFOX-7 in advanced gastric cancers (DOC-GC study). J Clin Oncol 2024;42(3_suppl): LBA248-LBA248. https://doi.org/10.1200/JCO.2024.42.3_suppl.LBA248</mixed-citation><mixed-citation xml:lang="en">Ramaswamy A., Bhargava P., Dubashi B., et al. A two-arm randomized open-label prospective design superiority phase III clinical trial to compare the efficacy of docetaxel-oxaliplatin-capecitabine/5 fluorouracil (DOC/F) followed by docetaxel versus CAPOX/mFOLFOX-7 in advanced gastric cancers (DOC-GC study). J Clin Oncol 2024;42(3_suppl): LBA248-LBA248. https://doi.org/10.1200/JCO.2024.42.3_suppl.LBA248</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Messager M., Lefevre J.H., Pichot-Delahaye V., et al. The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. Ann Surg 2011;254(5):684–93; https://doi.org/10.1097/SLA.0b013e3182352647</mixed-citation><mixed-citation xml:lang="en">Messager M., Lefevre J.H., Pichot-Delahaye V., et al. The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. Ann Surg 2011;254(5):684–93; https://doi.org/10.1097/SLA.0b013e3182352647</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sasako M., Sakuramoto S., Katai H., et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol 2011;29(33):4387–93. https://doi.org/10.1200/JCO.2011.36.5908</mixed-citation><mixed-citation xml:lang="en">Sasako M., Sakuramoto S., Katai H., et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol 2011;29(33):4387–93. https://doi.org/10.1200/JCO.2011.36.5908</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Noh S.H., Park S.R., Yang H.K., et al. Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial. Lancet Oncol 2014;15(12):1389–96. https://doi.org/10.1016/S1470-2045(14)70473-5</mixed-citation><mixed-citation xml:lang="en">Noh S.H., Park S.R., Yang H.K., et al. Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial. Lancet Oncol 2014;15(12):1389–96. https://doi.org/10.1016/S1470-2045(14)70473-5</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kozak K.R., Moody J.S. The survival impact of the intergroup 0116 trial on patients with gastric cancer. Int J Radiat Oncol Biol Phys 2008;72(2):517–21. https://doi.org/10.1016/j.ijrobp.2007.12.029</mixed-citation><mixed-citation xml:lang="en">Kozak K.R., Moody J.S. The survival impact of the intergroup 0116 trial on patients with gastric cancer. Int J Radiat Oncol Biol Phys 2008;72(2):517–21. https://doi.org/10.1016/j.ijrobp.2007.12.029</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ychou M., Boige V., Pignon J.P., et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol 2011;29(13):1715–21. https://doi.org/10.1200/JCO.2010.33.0597</mixed-citation><mixed-citation xml:lang="en">Ychou M., Boige V., Pignon J.P., et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol 2011;29(13):1715–21. https://doi.org/10.1200/JCO.2010.33.0597</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Cunningham D., Allum W.H., Stenning S.P., et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006;355(1):11–20. https://doi.org/10.1056/NEJMoa055531</mixed-citation><mixed-citation xml:lang="en">Cunningham D., Allum W.H., Stenning S.P., et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006;355(1):11–20. https://doi.org/10.1056/NEJMoa055531</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Batran S.E., Homann N., Pauligk C., et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet 2019;393(10184):1948–1957. https://doi.org/10.1016/S0140-6736(18)32557-1</mixed-citation><mixed-citation xml:lang="en">Al-Batran S.E., Homann N., Pauligk C., et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet 2019;393(10184):1948–1957. https://doi.org/10.1016/S0140-6736(18)32557-1</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Lutz M.P., Zalcberg J.R., Ducreux M., et al. The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma. Eur J Cancer 2019;112:1–8. https://doi.org/10.1016/j.ejca.2019.01.106</mixed-citation><mixed-citation xml:lang="en">Lutz M.P., Zalcberg J.R., Ducreux M., et al. The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma. Eur J Cancer 2019;112:1–8. https://doi.org/10.1016/j.ejca.2019.01.106</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sasako M., Sakuramoto S., Katai H., et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol 2011;29(33):4387–93. https://doi.org/10.1200/JCO.2011.36.5908</mixed-citation><mixed-citation xml:lang="en">Sasako M., Sakuramoto S., Katai H., et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol 2011;29(33):4387–93. https://doi.org/10.1200/JCO.2011.36.5908</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshida K., Kodera Y., Kochi M., et al. Addition of docetaxel to oral fluoropyrimidine improves efficacy in patients with stage III gastric cancer: interim analysis of JACCRO GC-07, a randomized controlled trial. J Clin Oncol 2019;37(15):1296–1304. https://doi.org/10.1200/JCO.18.01138</mixed-citation><mixed-citation xml:lang="en">Yoshida K., Kodera Y., Kochi M., et al. Addition of docetaxel to oral fluoropyrimidine improves efficacy in patients with stage III gastric cancer: interim analysis of JACCRO GC-07, a randomized controlled trial. J Clin Oncol 2019;37(15):1296–1304. https://doi.org/10.1200/JCO.18.01138</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Park S.H., Zang D.Y., Han B., et al. ARTIST 2: Interim results of a phase III trial involving adjuvant chemotherapy and/ or chemoradiotherapy after D2-gastrectomy in stage II/III gastric cancer (GC). J Clin Oncol 2019;37(15_suppl):4001. https://doi.org/10.1200/jco.2019.37.15_suppl.4001</mixed-citation><mixed-citation xml:lang="en">Park S.H., Zang D.Y., Han B., et al. ARTIST 2: Interim results of a phase III trial involving adjuvant chemotherapy and/ or chemoradiotherapy after D2-gastrectomy in stage II/III gastric cancer (GC). J Clin Oncol 2019;37(15_suppl):4001. https://doi.org/10.1200/jco.2019.37.15_suppl.4001</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Cunningham D., Allum W.H., Stenning S.P., et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006;355(1):11–20. https://doi.org/10.1056/NEJMoa055531</mixed-citation><mixed-citation xml:lang="en">Cunningham D., Allum W.H., Stenning S.P., et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006;355(1):11–20. https://doi.org/10.1056/NEJMoa055531</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Allum W.H., Stenning S.P., Bancewicz J., et al. Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer. J Clin Oncol 2009;27(30):5062–5067. https://doi.org/10.1200/JCO.2009.22.2083</mixed-citation><mixed-citation xml:lang="en">Allum W.H., Stenning S.P., Bancewicz J., et al. Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer. J Clin Oncol 2009;27(30):5062–5067. https://doi.org/10.1200/JCO.2009.22.2083</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Batran S. E, Homann N, Pauligk C., et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet 2019;393(10184):1948–1957. https://doi.org/10.1016/S0140-6736(18)32557-1</mixed-citation><mixed-citation xml:lang="en">Al-Batran S. E, Homann N, Pauligk C., et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet 2019;393(10184):1948–1957. https://doi.org/10.1016/S0140-6736(18)32557-1</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Van den Ende T., Veer E.T., Machiels M., et al. The efficacy and safety of (Neo)adjuvant therapy for gastric cancer: a network meta-analysis. Cancers (Basel) 2019;11(1):80. https://doi.org/10.3390/cancers11010080</mixed-citation><mixed-citation xml:lang="en">Van den Ende T., Veer E.T., Machiels M., et al. The efficacy and safety of (Neo)adjuvant therapy for gastric cancer: a network meta-analysis. Cancers (Basel) 2019;11(1):80. https://doi.org/10.3390/cancers11010080</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Trumper M., Ross P.J., Cunningham D., et al. Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials. Eur J Cancer 2006;42(7):827–34. https://doi.org/10.1016/j.ejca.2005.08.044</mixed-citation><mixed-citation xml:lang="en">Trumper M., Ross P.J., Cunningham D., et al. Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials. Eur J Cancer 2006;42(7):827–34. https://doi.org/10.1016/j.ejca.2005.08.044</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Jatoi A., Foster N.R., Egner J.R., et al. Older versus younger patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction, and stomach: a pooled analysis of eight consecutive North Central Cancer Treatment Group (NCCTG) trials. Int J Oncol 2010;36(3):601–6. https://doi.org/10.3892/ijo_00000535</mixed-citation><mixed-citation xml:lang="en">Jatoi A., Foster N.R., Egner J.R., et al. Older versus younger patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction, and stomach: a pooled analysis of eight consecutive North Central Cancer Treatment Group (NCCTG) trials. Int J Oncol 2010;36(3):601–6. https://doi.org/10.3892/ijo_00000535</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hall P.S., Lord S.R., Collinson M., et al. A randomised phase II trial and feasibility study of palliative chemotherapy in frail or elderly patients with advanced gastroesophageal cancer (321GO). Br J Cancer 2017;116(4):472–478. https://doi.org/10.1038/bjc.2016.442</mixed-citation><mixed-citation xml:lang="en">Hall P.S., Lord S.R., Collinson M., et al. A randomised phase II trial and feasibility study of palliative chemotherapy in frail or elderly patients with advanced gastroesophageal cancer (321GO). Br J Cancer 2017;116(4):472–478. https://doi.org/10.1038/bjc.2016.442</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang I.G., Ji J.H., Kang J.H., et al. A multi-center, open-label, randomized phase III trial of first-line chemotherapy with capecitabine monotherapy versus capecitabine plus oxaliplatin in elderly patients with advanced gastric cancer. J Geriatr Oncol 2017;8(3):170–175. https://doi.org/10.1016/j.jgo.2017.01.002</mixed-citation><mixed-citation xml:lang="en">Hwang I.G., Ji J.H., Kang J.H., et al. A multi-center, open-label, randomized phase III trial of first-line chemotherapy with capecitabine monotherapy versus capecitabine plus oxaliplatin in elderly patients with advanced gastric cancer. J Geriatr Oncol 2017;8(3):170–175. https://doi.org/10.1016/j.jgo.2017.01.002</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Hall P.S., Swinson D., Cairns D.A., et al. Efficacy of reduced-intensity chemotherapy with oxaliplatin and capecitabine on quality of life and cancer control among older and frail patients with advanced gastroesophageal cancer: the GO2 phase 3 randomized clinical trial. JAMA Oncol 2021;7(6):869–877. https://doi.org/10.1001/jamaoncol.2021.0848</mixed-citation><mixed-citation xml:lang="en">Hall P.S., Swinson D., Cairns D.A., et al. Efficacy of reduced-intensity chemotherapy with oxaliplatin and capecitabine on quality of life and cancer control among older and frail patients with advanced gastroesophageal cancer: the GO2 phase 3 randomized clinical trial. JAMA Oncol 2021;7(6):869–877. https://doi.org/10.1001/jamaoncol.2021.0848</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Thuss-Patience P.C., Kretzschmar A., Bichev D., et al. Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer--a randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Eur J Cancer 2011;47(15):2306–14. https://doi.org/10.1016/j.ejca.2011.06.002</mixed-citation><mixed-citation xml:lang="en">Thuss-Patience P.C., Kretzschmar A., Bichev D., et al. Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer--a randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Eur J Cancer 2011;47(15):2306–14. https://doi.org/10.1016/j.ejca.2011.06.002</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ford H.E., Marshall A., Bridgewater J.A., et al. Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial. Lancet Oncol 2014;15(1):78–86. https://doi.org/10.1016/S1470-2045(13)70549-7</mixed-citation><mixed-citation xml:lang="en">Ford H.E., Marshall A., Bridgewater J.A., et al. Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial. Lancet Oncol 2014;15(1):78–86. https://doi.org/10.1016/S1470-2045(13)70549-7</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Hironaka S., Ueda S., Yasui H., et al. Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 trial. J Clin Oncol 2013;31(35):4438–44. https://doi.org/10.1200/JCO.2012.48.5805</mixed-citation><mixed-citation xml:lang="en">Hironaka S., Ueda S., Yasui H., et al. Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 trial. J Clin Oncol 2013;31(35):4438–44. https://doi.org/10.1200/JCO.2012.48.5805</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Wilke H., Muro K., Van Cutsem E., et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastrooesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet Oncol 2014;15(11):1224–1235. https://doi.org/10.1016/S1470-2045(14)70420-6</mixed-citation><mixed-citation xml:lang="en">Wilke H., Muro K., Van Cutsem E., et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastrooesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet Oncol 2014;15(11):1224–1235. https://doi.org/10.1016/S1470-2045(14)70420-6</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kaya A.O., Coskun U., Gumus M., et al. The efficacy and toxicity of irinotecan with leucovorin and bolus and continuous infusional 5-fluorouracil (FOLFIRI) as salvage therapy for patients with advanced gastric cancer previously treated with platinum and taxane-based chemotherapy regimens. J Chemother 2012;24(4):217–20. https://doi.org/10.1179/1973947812Y.0000000020</mixed-citation><mixed-citation xml:lang="en">Kaya A.O., Coskun U., Gumus M., et al. The efficacy and toxicity of irinotecan with leucovorin and bolus and continuous infusional 5-fluorouracil (FOLFIRI) as salvage therapy for patients with advanced gastric cancer previously treated with platinum and taxane-based chemotherapy regimens. J Chemother 2012;24(4):217–20. https://doi.org/10.1179/1973947812Y.0000000020</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Maugeri-Saccà M., Pizzuti L., Sergi D., et al. FOLFIRI as a second-line therapy in patients with docetaxel-pretreated gastric cancer: a historical cohort. J Exp Clin Cancer Res 2013;32(1):67. https://doi.org/10.1186/1756-9966-32-67</mixed-citation><mixed-citation xml:lang="en">Maugeri-Saccà M., Pizzuti L., Sergi D., et al. FOLFIRI as a second-line therapy in patients with docetaxel-pretreated gastric cancer: a historical cohort. J Exp Clin Cancer Res 2013;32(1):67. https://doi.org/10.1186/1756-9966-32-67</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Sendur M.A., Ozdemir N., Özatlı T., et al. Comparison the efficacy of second-line modified EOX (epirubicin, oxaliplatin, and capecitabine) and irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) regimens in metastatic gastric cancer patients that progressed on first-line modified docetaxel and cisplatin plus fluorouracil (DCF) regimen. Med Oncol 2014;31(9):153. https://doi.org/10.1007/s12032-014-0153-y</mixed-citation><mixed-citation xml:lang="en">Sendur M.A., Ozdemir N., Özatlı T., et al. Comparison the efficacy of second-line modified EOX (epirubicin, oxaliplatin, and capecitabine) and irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) regimens in metastatic gastric cancer patients that progressed on first-line modified docetaxel and cisplatin plus fluorouracil (DCF) regimen. Med Oncol 2014;31(9):153. https://doi.org/10.1007/s12032-014-0153-y</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Jung J.Y., Ryu M.H., Ryoo B.Y., et al. Second-line irinotecan, leucovorin, and 5-fluorouracil for gastric cancer patients after failed docetaxel and S-1. Gastroenterol Res Pract 2016;2016:6857625. https://doi.org/10.1155/2016/6857625</mixed-citation><mixed-citation xml:lang="en">Jung J.Y., Ryu M.H., Ryoo B.Y., et al. Second-line irinotecan, leucovorin, and 5-fluorouracil for gastric cancer patients after failed docetaxel and S-1. Gastroenterol Res Pract 2016;2016:6857625. https://doi.org/10.1155/2016/6857625</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Klempner S.J., Maron S.B., Chase L., et al. Initial report of second-line FOLFIRI in combination with ramucirumab in advanced gastroesophageal adenocarcinomas: a multi-institutional retrospective analysis. Oncologist 2019;24(4):475–482. https://doi.org/10.1634/theoncologist.2018-0602</mixed-citation><mixed-citation xml:lang="en">Klempner S.J., Maron S.B., Chase L., et al. Initial report of second-line FOLFIRI in combination with ramucirumab in advanced gastroesophageal adenocarcinomas: a multi-institutional retrospective analysis. Oncologist 2019;24(4):475–482. https://doi.org/10.1634/theoncologist.2018-0602</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Бесова Н.С., Титова Т.А., Строяковский Д.Л. и соавт. Результаты применения рамуцирумаба с иринотеканом и фторпиримидинами во второй линии лечения больных диссеминированным раком желудка. Медицинский совет 2019;10:100–109. https://doi.org/10.21518/2079-701X-2019-10-100-109</mixed-citation><mixed-citation xml:lang="en">Besova N.S., Titova T.A., Stroyakovsky D.L., et al. Results of the use of ramucirumab in combination with irinotecan and fluoropyrimidines in the second-line chemotherapy for disseminated gastric cancer. Meditsinsky Sovet 2019;10:100–109 (In Russ.). https://doi.org/10.21518/2079-701X-2019-10-100-109</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Lorenzen S., Thuss-Patiens P., Pauligk C., et al. FOLFIRI plus ramucirumab versus paclitaxel plus ramucirumab for patients with advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction as second-line therapy: Interim safety and efficacy results from the phase II RAMIRIS Study (AIO-STO-0415) of the German Gastric Group at AIO. Journal of Clinical Oncology 38(15_suppl):4514–4514. https://doi.org/10.1200/JCO.2020.38.15suppl.4514</mixed-citation><mixed-citation xml:lang="en">Lorenzen S., Thuss-Patiens P., Pauligk C., et al. FOLFIRI plus ramucirumab versus paclitaxel plus ramucirumab for patients with advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction as second-line therapy: Interim safety and efficacy results from the phase II RAMIRIS Study (AIO-STO-0415) of the German Gastric Group at AIO. Journal of Clinical Oncology 38(15_suppl):4514–4514. https://doi.org/10.1200/JCO.2020.38.15suppl.4514</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Sym S.J., Hong J., Park J., et al. A randomized phase II study of biweekly irinotecan monotherapy or a combination of irinotecan plus 5-fluorouracil/leucovorin (mFOLFIRI) in patients with metastatic gastric adenocarcinoma refractory to or progressive after first-line chemotherapy. Cancer Chemother Pharmacol 2013;71(2):481–8. https://doi.org/10.1007/s00280-012-2027-3</mixed-citation><mixed-citation xml:lang="en">Sym S.J., Hong J., Park J., et al. A randomized phase II study of biweekly irinotecan monotherapy or a combination of irinotecan plus 5-fluorouracil/leucovorin (mFOLFIRI) in patients with metastatic gastric adenocarcinoma refractory to or progressive after first-line chemotherapy. Cancer Chemother Pharmacol 2013;71(2):481–8. https://doi.org/10.1007/s00280-012-2027-3</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Tanabe K., Fujii M., Nishikawa K., et al. Phase II/III study of second-line chemotherapy comparing irinotecan-alone with S-1 plus irinotecan in advanced gastric cancer refractory to first-line treatment with S-1 (JACCRO GC-05). Ann Oncol 2015;26(9):1916–1922. https://doi.org/10.1093/annonc/mdv265</mixed-citation><mixed-citation xml:lang="en">Tanabe K., Fujii M., Nishikawa K., et al. Phase II/III study of second-line chemotherapy comparing irinotecan-alone with S-1 plus irinotecan in advanced gastric cancer refractory to first-line treatment with S-1 (JACCRO GC-05). Ann Oncol 2015;26(9):1916–1922. https://doi.org/10.1093/annonc/mdv265</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Shitara K., Özgüroğlu M., Bang Y.J., et al. Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial. Lancet 2018;392(10142):123–133. https://doi.org/10.1016/S0140-6736(18)31257-1</mixed-citation><mixed-citation xml:lang="en">Shitara K., Özgüroğlu M., Bang Y.J., et al. Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial. Lancet 2018;392(10142):123–133. https://doi.org/10.1016/S0140-6736(18)31257-1</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Chao J., Fuchs C.S., Shitara K., et al. Assessment of pembrolizumab therapy for the treatment of microsatellite instability-high gastric or gastroesophageal junction cancer among patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 clinical trials. JAMA Oncol 2021;7(6):895–902. https://doi.org/10.1001/jamaoncol.2021.0275.</mixed-citation><mixed-citation xml:lang="en">Chao J., Fuchs C.S., Shitara K., et al. Assessment of pembrolizumab therapy for the treatment of microsatellite instability-high gastric or gastroesophageal junction cancer among patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 clinical trials. JAMA Oncol 2021;7(6):895–902. https://doi.org/10.1001/jamaoncol.2021.0275.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
