tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2011-1-29-39tumors-142Research ArticleМАТЕРИАЛЫ КОНФЕРЕНЦИЙLECTUREПочечно-клеточный рак у пациентов, находящихся на диализеISHIKAWAISAOisikawai@kanazawa-med.ac.jpIsao Ishikawa, Division of Nephrol- ogy, Department of Internal Medicine, Asanogawa General Hospital, 83 KosakaNaka, Kanazawa, 920-8621, Ishikawa, Japan. Tel. +81 76-252-2101Japan201103082015112939Copyright © ISHIKAWA I., 20152015ISHIKAWA I.ISHIKAWA I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/142

Заболеваемость почечно-клеточным раком (ПКР) у пациентов, находящихся на диализе, выше, чем в общей популяции. Чем дольше больной получает гемодиализ, тем выше заболеваемость ПКР. Риск развития ПКР связан с формированием поликистоза почек. Некоторые виды ПКР у пациентов, находящихся на гемодиализе, или пациентов с заболеваниями почек поздних стадий не соответствуют гистологической классификации ПКР, представленной Всемирной Организацией Здравоохранения. Такие опухоли отличаются от спорадических; их называют ПКР, ассоциированным с приобретенным поликистозом почек (ППКП), или светлоклеточным-папиллярным ПКР у пациентов с заболеваниями почек поздних стадий. Рак почки на фоне ППКП развивается у пациентов, которые получают диализ длительно (более 10 лет). В связи с высокой заболеваемостью и отсутствием симптомов, пациентов находящихся на диализе из группы высокого риска, необходимо обследовать на предмет ПКР. Такой скрининг особенно важен для пациентов на диализе продолжительностью более 10 лет, пациентам с тяжелым ППКП и кандидатам на трансплантацию почки. Опухоль в почке, прилежащая к множественным приобретенным кистам, как правило, мало или совсем не накапливает контрастное вещество при КТ, а также не выступает за контур почки. Таким образом, дооперационная оценка ПКР у пациентов на длительном диализе затруднительна. 

приобретенные кисты почекгемодиализпочечно-клеточный ракПКР на фоне ППКПультразвуковое исследование с контрастированием с использованием перфторбутановых микропузырьковПЭТ-КТКТ.
ReferencesIshikawa I: Acquired Cystic Disease of the Kidney and Renal Cell Carcinoma-Complication of Long-Term Hemodialysis, Springer ,Tokyo. 1-111, 2007Ishikawa I: Acquired Cystic Disease of the Kidney and Renal Cell Carcinoma-Complication of Long-Term Hemodialysis, Springer ,Tokyo. 1-111, 2007Ishikawa I, Saito Y, Onouchi Z, Kitada H, Suzuki S, Kurihara S, Yuri T, Shinoda A: Development of acquired cystic disease and adenocarcinoma of the kidney in glomerulonephritic chronic hemodialysis patients. Clin Nephrol 14: 1-6, 1980Ishikawa I, Saito Y, Onouchi Z, Kitada H, Suzuki S, Kurihara S, Yuri T, Shinoda A: Development of acquired cystic disease and adenocarcinoma of the kidney in glomerulonephritic chronic hemodialysis patients. Clin Nephrol 14: 1-6, 1980Ishikawa I, Onouchi Z, Saito Y, Tateishi K, Shinoda A, Suzuki S, Kitada H, Sugishita N, Fukuda Y: Sex differences in acquired cystic disease of the kidney on long-term dialysis. Nephron 39: 336-340, 1985Ishikawa I, Onouchi Z, Saito Y, Tateishi K, Shinoda A, Suzuki S, Kitada H, Sugishita N, Fukuda Y: Sex differences in acquired cystic disease of the kidney on long-term dialysis. Nephron 39: 336-340, 1985Ishikawa I, Hayama S, Morita K, Nakazawa T, Yokoyama H, Honda R, Satoh K, Kakuma T: Long-term natural history of acquired cystic disease of the kidney. Ther Apher Dial: 14:409-416, 2010Ishikawa I, Hayama S, Morita K, Nakazawa T, Yokoyama H, Honda R, Satoh K, Kakuma T: Long-term natural history of acquired cystic disease of the kidney. Ther Apher Dial: 14:409-416, 2010Ishikawa I, Saito Y, Asaka M, Tomosugi N, Yuri T, Watanabe M, Honda R: Twenty-year follow-up of acquired renal cystic disease. Clin Nephrol 59: 153-159, 2003Ishikawa I, Saito Y, Asaka M, Tomosugi N, Yuri T, Watanabe M, Honda R: Twenty-year follow-up of acquired renal cystic disease. Clin Nephrol 59: 153-159, 2003Ishikawa I: Uremic acquired cystic disease of kidney. Urology 26: 101-108, 1985Ishikawa I: Uremic acquired cystic disease of kidney. Urology 26: 101-108, 1985Ishikawa I: Present status of renal cell carcinoma in dialysis patients :A questionnaire study in 2004 and review of past questionnaires since 1982 (in Japanese with English abstract). J Jpn Soc Dial Ther 38: 1689-1700, 2005Ishikawa I: Present status of renal cell carcinoma in dialysis patients :A questionnaire study in 2004 and review of past questionnaires since 1982 (in Japanese with English abstract). J Jpn Soc Dial Ther 38: 1689-1700, 2005Ishikawa I: Present status of acquired cystic disease of the kidney (in Japanese). J Jpn Ass Dial Physicians 23: 179-187, 2008Ishikawa I: Present status of acquired cystic disease of the kidney (in Japanese). J Jpn Ass Dial Physicians 23: 179-187, 2008Dunnill MS, Millard PR, Oliver D: Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance haemodialysis. J. Clin. Pathol. 30: 868-877, 1977Dunnill MS, Millard PR, Oliver D: Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance haemodialysis. J. Clin. Pathol. 30: 868-877, 1977Hughson MD, Hennigar GR, McManus JFA: Atypical cysts, acquired renal cystic disease, and renal cell tumors in end stage dialysis kidneys. Lab. Invest. 42: 475-480, 1980Hughson MD, Hennigar GR, McManus JFA: Atypical cysts, acquired renal cystic disease, and renal cell tumors in end stage dialysis kidneys. Lab. Invest. 42: 475-480, 1980Eble IN, Sauter G, Epstein JI, al. e: WHO classification of tumours. In: Pathology and Genetics:Tumours of the Urinary System and Male Genital Organs. Lyon, France: IARC Press. 2004Eble IN, Sauter G, Epstein JI, al. e: WHO classification of tumours. In: Pathology and Genetics:Tumours of the Urinary System and Male Genital Organs. Lyon, France: IARC Press. 2004Ishikawa I, Kovacs G: High incidence of papillary renal cell tumours in patients on chronic haemodialysis. Histopathology 22: 135-139, 1993Ishikawa I, Kovacs G: High incidence of papillary renal cell tumours in patients on chronic haemodialysis. Histopathology 22: 135-139, 1993Ishikawa I, Shinoda A: Renal adenocarcinoma with or without acquired cysts in chronic hemodialysis patients. Clin Nephrol 20: 321-322, 1983Ishikawa I, Shinoda A: Renal adenocarcinoma with or without acquired cysts in chronic hemodialysis patients. Clin Nephrol 20: 321-322, 1983Ishikawa I: Prognosis in dialysis patients complicated with renal cell carcinoma (in Japanese with English abstract). J Jpn Ass Soc Dial Ther 35: 287-293, 2002Ishikawa I: Prognosis in dialysis patients complicated with renal cell carcinoma (in Japanese with English abstract). J Jpn Ass Soc Dial Ther 35: 287-293, 2002Ishikawa I: Present status of renal cell carcinoma in dialysis patients in Japan: questionnaire study in 2002. Nephron Clin Pract 97: c11-16, 2004Ishikawa I: Present status of renal cell carcinoma in dialysis patients in Japan: questionnaire study in 2002. Nephron Clin Pract 97: c11-16, 2004Ishikawa I, Yuri T, Kitada H, Shinoda A: Regression of acquired cystic disease of the kidney after successful renal transplantation. Am J Nephrol 3: 310-314, 1983Ishikawa I, Yuri T, Kitada H, Shinoda A: Regression of acquired cystic disease of the kidney after successful renal transplantation. Am J Nephrol 3: 310-314, 1983Sule N, Yakupoglu U, Shen SS, Krishnan B, Yang G, Lerner S, Sheikh-Hamad D, Truong LD: Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease: a comprehensive study. Am J Surg Pathol 29: 443-451, 2005Sule N, Yakupoglu U, Shen SS, Krishnan B, Yang G, Lerner S, Sheikh-Hamad D, Truong LD: Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease: a comprehensive study. Am J Surg Pathol 29: 443-451, 2005Tickoo SK, dePeralta-Venturina MN, Harik LR, Worcester HD, Salama ME, Young AN, Moch H, Amin MB: Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. Am J Surg Pathol 30: 141-153, 2006Tickoo SK, dePeralta-Venturina MN, Harik LR, Worcester HD, Salama ME, Young AN, Moch H, Amin MB: Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. Am J Surg Pathol 30: 141-153, 2006Nouh MA, Kuroda N, Yamashita M, Hayashida Y, Yano T, Minakuchi J, Taniguchi S, Nomura I, Inui M, Sugimoto M, Kakehi Y: Renal cell carcinoma in patients with endstage renal disease: relationship between histological type and duration of dialysis. BJU Int, 2009Nouh MA, Kuroda N, Yamashita M, Hayashida Y, Yano T, Minakuchi J, Taniguchi S, Nomura I, Inui M, Sugimoto M, Kakehi Y: Renal cell carcinoma in patients with endstage renal disease: relationship between histological type and duration of dialysis. BJU Int, 2009Zamin-Khamesh N, Zhai Q, Truong LD: Renal cell carcinoma with calcium oxalate deposition A distinct type of renal cell carcinoma within the spectrum of renal neoplasms associated with acquired cystic kidney disease. Pathology Case Reviews 15: 14-19, 2010Zamin-Khamesh N, Zhai Q, Truong LD: Renal cell carcinoma with calcium oxalate deposition A distinct type of renal cell carcinoma within the spectrum of renal neoplasms associated with acquired cystic kidney disease. Pathology Case Reviews 15: 14-19, 2010Cossu-Rocca P, Eble JN, Zhang S, Martignoni G, Brunelli M, Cheng L: Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study. Mod Pathol 19: 780-787, 2006 22. Pan CC, Chen YJ, Chang LC, Chang YH, Ho DM: Immunohistochemical and molecular genetic profiling of acquired cystic disease-associated renal cell carcinoma. Histopathology 55: 145-153, 2009Cossu-Rocca P, Eble JN, Zhang S, Martignoni G, Brunelli M, Cheng L: Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study. Mod Pathol 19: 780-787, 2006 22. Pan CC, Chen YJ, Chang LC, Chang YH, Ho DM: Immunohistochemical and molecular genetic profiling of acquired cystic disease-associated renal cell carcinoma. Histopathology 55: 145-153, 2009Japanese Urological Association, Japanese Society of Pathology, Japan-Radiological-Society: General Rule for Clinical and Pathological Studies on Renal Cell Carcinoma (in Japanese). ed 3. Tokyo, Kanehara Syuppan. 1999Japanese Urological Association, Japanese Society of Pathology, Japan-Radiological-Society: General Rule for Clinical and Pathological Studies on Renal Cell Carcinoma (in Japanese). ed 3. Tokyo, Kanehara Syuppan. 1999Ishikawa I: Acquired cysts and cancer of failing kidneys, Cancer and the Kidney, 2nd Ed, Cohen EP, Ed, Oxford University Press, in press. 2010Ishikawa I: Acquired cysts and cancer of failing kidneys, Cancer and the Kidney, 2nd Ed, Cohen EP, Ed, Oxford University Press, in press. 2010Japanese-Urological-Association: Clinical Practice Guideline for Renal Cell Carcinoma, 2007 ed (in Japanese), Tokyo, Kanehara Syuppan. 1-66, 2007Japanese-Urological-Association: Clinical Practice Guideline for Renal Cell Carcinoma, 2007 ed (in Japanese), Tokyo, Kanehara Syuppan. 1-66, 2007Terasawa Y, Hirota M, Sudo S: Detection of renal cell carcinoma detection by ultrasonography at health checkup (in Japanese). Japanese Association for Cancer Detection and Diagnosis 15: 166-171, 2008Terasawa Y, Hirota M, Sudo S: Detection of renal cell carcinoma detection by ultrasonography at health checkup (in Japanese). Japanese Association for Cancer Detection and Diagnosis 15: 166-171, 2008Marumo K, Satomi Y, Miyao N, Hasegawa M, Tomita Y, Igarashi T, Onishi T, Nakazawa H, Fukuda M, Ozono S, Terachi T, Tsushima T, Nakamoto T, Kawamura J: The prevalence of renal cell carcinoma: a nation-wide survey in Japan in 1997. Int J Urol 8: 359-365, 2001Marumo K, Satomi Y, Miyao N, Hasegawa M, Tomita Y, Igarashi T, Onishi T, Nakazawa H, Fukuda M, Ozono S, Terachi T, Tsushima T, Nakamoto T, Kawamura J: The prevalence of renal cell carcinoma: a nation-wide survey in Japan in 1997. Int J Urol 8: 359-365, 2001Ishikawa I, Saito Y, Nakamura M, Takada K, Ishii H, Nakazawa T, Fukuda Y, Asaka M, Tomosugi N, Yuri T: Fifteenyear follow-up of acquired renal cystic disease a gender difference. Nephron 75: 315-320, 1997Ishikawa I, Saito Y, Nakamura M, Takada K, Ishii H, Nakazawa T, Fukuda Y, Asaka M, Tomosugi N, Yuri T: Fifteenyear follow-up of acquired renal cystic disease a gender difference. Nephron 75: 315-320, 1997Ishikawa I, Honda R, Yamada Y, Kakuma T: Renal cell carcinoma detected by screening shows better patient survival than that detected following symptoms in dialysis patients. Ther Apher Dial 8: 468-473, 2004Ishikawa I, Honda R, Yamada Y, Kakuma T: Renal cell carcinoma detected by screening shows better patient survival than that detected following symptoms in dialysis patients. Ther Apher Dial 8: 468-473, 2004Schwarz A, Vatandaslar S, Merkel S, Haller H: Renal cell carcinoma in transplant recipients with acquired cystic kidney disease. Clin J Am Soc Nephrol 2: 750-756, 2007Schwarz A, Vatandaslar S, Merkel S, Haller H: Renal cell carcinoma in transplant recipients with acquired cystic kidney disease. Clin J Am Soc Nephrol 2: 750-756, 2007Brown EA: Renal tumours in dialysis patients: who should we screen? Nephron Clin Pract 97: c3-4, 2004Brown EA: Renal tumours in dialysis patients: who should we screen? Nephron Clin Pract 97: c3-4, 2004Sarasin FP, Wong JB, Levey AS, Meyer KB: Screening for acquired cystic kidney disease: a decision analytic perspective. Kidney Int 48: 207-219, 1995Sarasin FP, Wong JB, Levey AS, Meyer KB: Screening for acquired cystic kidney disease: a decision analytic perspective. Kidney Int 48: 207-219, 1995Scandling JD: Acquired cystic kidney disease and renal cell cancer after transplantation: time to rethink screening? Clin J Am Soc Nephrol 2: 621-622, 2007Scandling JD: Acquired cystic kidney disease and renal cell cancer after transplantation: time to rethink screening? Clin J Am Soc Nephrol 2: 621-622, 2007Ishikawa I: Uremic acquired renal cystic disease. Natural history and complications [editorial]. Nephron 58: 257-267, 1991Ishikawa I: Uremic acquired renal cystic disease. Natural history and complications [editorial]. Nephron 58: 257-267, 1991Takebayashi S, Hidai H, Chiba T, Takagi H, Koike S, Matsubara S: Using helical CT to evaluate renal cell carcinoma in patients undergoing hemodialysis: value of early enhanced images. Am. J. Roentgenol. 172: 429-433, 1999Takebayashi S, Hidai H, Chiba T, Takagi H, Koike S, Matsubara S: Using helical CT to evaluate renal cell carcinoma in patients undergoing hemodialysis: value of early enhanced images. Am. J. Roentgenol. 172: 429-433, 1999Akiyama T, Onoue A: Sonazoid-enhanced ultrasonography: adiagnosis of kidney and prostate disease (in Japanese). Innervision 22: 41-45, 2007Akiyama T, Onoue A: Sonazoid-enhanced ultrasonography: adiagnosis of kidney and prostate disease (in Japanese). Innervision 22: 41-45, 2007Ak I, Can C: F-18 FDG PET in detecting renal cell carcinoma. Acta Radiol 46: 895-899, 2005Ak I, Can C: F-18 FDG PET in detecting renal cell carcinoma. Acta Radiol 46: 895-899, 2005Ozawa N, Okamura T, Koyama K, Hamazawa Y, Senzaki H, Tanabe S, Ikemoto S, Inoue Y: Usefulness of F-18 FDGPET in a long-term hemodialysis patient with renal cell carcinoma and pheochromocytoma. Ann Nucl Med 21: 239-243, 2007Ozawa N, Okamura T, Koyama K, Hamazawa Y, Senzaki H, Tanabe S, Ikemoto S, Inoue Y: Usefulness of F-18 FDGPET in a long-term hemodialysis patient with renal cell carcinoma and pheochromocytoma. Ann Nucl Med 21: 239-243, 2007Shinsako K, Mizuno T, Terada T, Watanabe J, Kamba T, Nakamura E, Ogawa O, Inui KI: Tolerable sorafenib therapy for a renal cell carcinoma patient with hemodialysis: a case study. Int J Clin Oncol, 2010Shinsako K, Mizuno T, Terada T, Watanabe J, Kamba T, Nakamura E, Ogawa O, Inui KI: Tolerable sorafenib therapy for a renal cell carcinoma patient with hemodialysis: a case study. Int J Clin Oncol, 2010Ishikawa I: Cancer in dialysis patients. Cancer and the Kidney, Cohen EP, ed, Oxford University Press, Oxford: 227-247, 2005Ishikawa I: Cancer in dialysis patients. Cancer and the Kidney, Cohen EP, ed, Oxford University Press, Oxford: 227-247, 2005

The authors declare that there are no conflicts of interest present.