tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2024-010tumors-1329Research ArticleОБЗОРЫ И АНАЛИТИКАREVIEWS AND ANALYSISСовременный взгляд на проблему: влияние ожирения как ключевого компонента метаболического синдрома на развитие и прогрессирование рака эндометрияModern view of the problem: the influence of obesity as a key component of metabolic syndrome on the development and progression of endometrial cancerhttps://orcid.org/0000-0002-2905-7735ПавловА. Ю.PavlovA. Yu.

Андрей Юрьевич Павлов

117997; ул. Профсоюзная, 86; Москва

Andrei Yurevich Pavlov

117997; 86, Profsoyuznaya St.; Moscow

https://orcid.org/0000-0001-5789-375XДзидзарияА. Г.DzidzariyaA. G.

Александр Гудисович Дзидзария 

117997; ул. Профсоюзная, 86; Москва

Aleksandr Gudisovich Dzidzariya

117997; 86, Profsoyuznaya St.; Moscow

https://orcid.org/0000-0002-4873-667XКалинченкоС. Ю.KalinchenkoS. Yu.

Светлана Юрьевна Калинченко

117198; ул. Миклухо‑Маклая, 6; Москва

Svetlana Yurevna Kalinchenko

117198; 6 Miklukho‑Maklaya St.; Moscow

https://orcid.org/0009-0009-4683-5349МуравьеваП. В.MuravyevaP. V.

Полина Владимировна Муравьева

117997; ул. Профсоюзная, 86; Москва

Polina Vladimirovna Muraveva

117997; 86, Profsoyuznaya St.; Moscow

polina_muraveva99@mail.ruФГБУ «Российский научный центр рентгенорадиологии» Минздрава РосcииРоссияRussian Scientific Center of Roentgen RadiologyRussian FederationФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»РоссияPeoples’ Friendship University of Russia named after Patrice LumumbaRussian Federation2024220720241427582Copyright © Павлов А.Ю., Дзидзария А.Г., Калинченко С.Ю., Муравьева П.В., 20242024Павлов А.Ю., Дзидзария А.Г., Калинченко С.Ю., Муравьева П.В.Pavlov A.Y., Dzidzariya A.G., Kalinchenko S.Y., Muravyeva P.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/1329

   В отличие от многих других злокачественных новообразований, заболеваемость и смертность от рака эндометрия продолжает расти. Эта неприятная тенденция в немалой мере является результатом всемирной эпидемии ожирения, которая вызвана сниженной физической активностью, неправильным питанием и хроническим стрессом. В настоящее время более 50 % случаев рака эндометрия связаны с ожирением, которое признано независимым фактором рискаразвития этого заболевания. Жировая ткань является не только основным местом хранения избыточной энергии, но и полноценным эндокринным органом, оказывающим влияние на обмен веществ, иммунный ответ и выработку биологически активных веществ, участвующих в росте и дифференцировке клеток, ангиогенезе, апоптозе и канцерогенезе. В данном обзоре мы оцениваем влияние ожирения как ключевого компонента метаболического синдрома на развитие и прогрессирование рака эндометрия. Существует несколько механизмов, с помощью которых ожирение увеличивает риск развития рака эндометрия, включая повышение уровня эндогенных половых стероидных гормонов, гипергликемию, инсулинорезистентность, секрецию адипокинов и хроническое воспаление.

   Целью данного обзора является анализ публикаций, отражающий уже известные аспекты биологического действия ожирения, а также новые данные последних лет.

   Unlike many other malignancies, the incidence and mortality of endometrial cancer continues to rise. This unfortunate trend is in no small part the result of the worldwide obesity epidemic, which is caused by reduced physical activity, poor diet and chronic stress. Currently, more than 50 % of endometrial cancer cases are associated with obesity, which is recognized as an independent risk factor for the development of this disease. Adipose tissue is not only the main place of storage of excess energy, but also a full-fledged endocrine organ that affects the metabolism, immune response and production of biologically active substances involved in cell growth and differentiation, angiogenesis, apoptosis and carcinogenesis. In this review, we assess the impact of obesity as a key component of metabolic syndrome on the development and progression of endometrial cancer. There are several mechanisms by which obesity enlarges the risk of endometrial cancer, including increased endogenous sex steroid hormones, hyperglycemia, insulin resistance, adipokine secretion, and chronic inflammation.

   The purpose of this review is to analyze publications, reflecting the already known aspects of the biological effect of obesity, as well as new data from recent years.

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The authors declare that there are no conflicts of interest present.