tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2024-14-1-67-73tumors-1293Research ArticleОБЗОРЫ И АНАЛИТИКАREVIEWS AND ANALYSISЗначение клеток воспаления опухолевого микроокружения при раке молочной железыImportance of tumor microenvironment inflammation cells in breast cancerhttps://orcid.org/0000-0003-4460-9136ТитовК. С.TitovК. S.

Титов Константин Сергеевич

125284 Москва, 2-й Боткинский пр-д, 5; 117198 Москва, ул. Миклухо-Маклая, 6

Titov Konstantin Sergeevich

5 2 nd Botkinskiy Proezd, Moscow 125284; 6 Miklukho‑Maklaya St., Moscow 117198

https://orcid.org/0000-0001-8391-1210ГрековД. Н.GrekovD.  N.

Греков Дмитрий Николаевич

125284 Москва, 2-й Боткинский пр-д, 5; 125993 Москва, ул. Баррикадная, 2/1, стр. 1

Grekov Dmitrii Nikolaevich

5 2 nd Botkinskiy Proezd, Moscow 125284; ; Build. 1, 2 / 1 Barrikadnaya St.,Moscow 125993

https://orcid.org/0000-0001-8613-9609ЗакурдаевЕ. И.ZakurdaevЕ. I.

Закурдаев Евгений Иванович

125284 Москва, 2-й Боткинский пр-д, 5

Zakurdaev Evgenii Ivanovich

5 2 nd Botkinskiy Proezd, Moscow 125284

https://orcid.org/0000-0002-4698-7184ЛориеЗ. В.LorieZ. V.

Лорие Зоя Викторовна

125284 Москва, 2-й Боткинский пр-д, 5

Lorie Zoya Viktorovna

5 2 nd Botkinskiy Proezd, Moscow 125284

zoelorie@mail.ruhttps://orcid.org/0000-0001-6373-1888ПаклинаО. В.PaklinaО. V.

Паклина Оксана Владимировна

125284 Москва, 2-й Боткинский пр-д, 5

Paklina Oksana Vladimirovna

5 2 nd Botkinskiy Proezd, Moscow 125284

https://orcid.org/0000-0003-4021-9085ГордиенкоЕ. Н.GordienkoЕ. N.

Гордиенко Елена Николаевна

125284 Москва, 2-й Боткинский пр-д, 5

Gordienko Elena Nikolaevna

5 2 nd Botkinskiy Proezd, Moscow 125284

ГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»; ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»РоссияS. P. Botkin City Clinical Hospital, Moscow Healthcare Department; Peoples' Friendship University of Russia named after Patrice LumumbaRussian FederationГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияS. P. Botkin City Clinical Hospital, Moscow Healthcare Department; Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian FederationГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»РоссияS. P. Botkin City Clinical Hospital, Moscow Healthcare DepartmentRussian Federation2024150320241416773Copyright © Титов К.С., Греков Д.Н., Закурдаев Е.И., Лорие З.В., Паклина О.В., Гордиенко Е.Н., 20242024Титов К.С., Греков Д.Н., Закурдаев Е.И., Лорие З.В., Паклина О.В., Гордиенко Е.Н.Titov К.S., Grekov D.N., Zakurdaev Е.I., Lorie Z.V., Paklina О.V., Gordienko Е.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/1293

В данном обзоре анализируется роль воспалительного компонента опухолевого микроокружения при раке молочной железы. Описывается участие опухоль-ассоциированных макрофагов, нейтрофилов и тучных клеток в инициации, пролиферации и метастазировании опухоли. Раскрываются методики оценки воспалительных клеток опухолевого микроокружения для выбора лекарственной терапии и прогнозирования лечебного ответа. Известно, что макрофаги стимулируют опухолевый рост, способствуя инвазии и метастазированию опухолевых клеток. Также и нейтрофилы являются представителями опухолевого микроокружения при различных злокачественных новообразованиях, способные вызывать местную иммуносупрессию. Влияние тучных клеток на усиление опухолевого роста пока еще спорно. Основная способность тучных клеток — это стимулирование неоангиогенеза, который усиливает опухолевую прогрессию.

This review evaluates the role of the tumor microenvironment of breast cancer focusing on the evidence showing that tumor-associated macrophages, neutrophils, and mast cells directly participate in tumor initiation, proliferation, and metastasizing. This study also describes microenvironment cells pathologic assessment relevant for prognostication and treatment decision. Tumor-associated macrophages stimulate breast tumor progression, including tumor cell growth, invasion and metastasizing. Tumor-associated neutrophils are more prevalent in patients with severe disease or resistance to treatment and it can be explained by their pro-tumor / immunosuppressive characteristics. The contribution of mast cells to tumor development and progression appears to be a controversial area of research. The ability of mast cells to promote angiogenesis is viewed as a key process in promoting tumor development. However, elevated level of mast cells at tumor sites seems to be connected with improved outcomes.

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The authors declare that there are no conflicts of interest present.