References

tumors

Malignant tumours

2224-50572587-6813

Rosoncoweb

10.18027/2224-5057-2023-13-3s1-53-63

tumors-1185

Research Article

Статьи

Влияние микробиоты кожи на дерматологические реакции при проведении химиотерапии

Кретова

К. А.

Кретова

К. А.

Новосибирск

kamilla.armanovna@bk.ru

Маркина

В. А.

Маркина

В. А.

Новосибирск

Новиков

С. С.

Новиков

С. С.

Новосибирск

Сергеева

И. Г.

Сергеева

И. Г.

Новосибирск

Филипенко

М. Л.

Филипенко

М. Л.

Новосибирск

Сидоров

С. В.

Сидоров

С. В.

Новосибирск

ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет»РоссияФГАОУ ВО «Новосибирский национальный исследовательский государственный университет»Russian Federation

Институт химической биологии и фундаментальной медицины СО РАНРоссияИнститут химической биологии и фундаментальной медицины СО РАНRussian Federation

ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет»; ГБУЗ Новосибирской области «Городская клиническая больница № 1»РоссияФГАОУ ВО «Новосибирский национальный исследовательский государственный университет»; ГБУЗ Новосибирской области «Городская клиническая больница № 1»Russian Federation

2023

23112023

133s15363

2023

Кретова К.А., Маркина В.А., Новиков С.С., Сергеева И.Г., Филипенко М.Л., Сидоров С.В.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.malignanttumors.org/jour/article/view/1185

В настоящее время микробиому уделяется все больше внимания. Проводилось и проводится до сих пор множество исследований по влиянию микробиома человека на возникновение, течение различных заболеваний. В настоящее время существует теория о влиянии микробиоты кожи на возникновение кожной токсичности у онкологических больных. При проведении лекарственной терапии онкологических больных существуют различные нежелательные реакции,которые могут влиять на частоту и длительность проведения лечения. К наименее изученным можно отнести дерматологические реакции. Индуцированной химиотерапией повреждение клеток изменяет микробную среду. Но до сих пор в этой области существует пробел в знаниях о механизме дисбиоза микробиоты кожи, приводящей к кожной токсичности. Понимание микробиоты кожи и его связи с кожной токсичностью, связанной с химиотерапией, может помочь в развитии стратегического планирования и терапевтического вмешательства, повышающих качество жизни пациентов.

микробиомрак молочной железыкожная токсичностьхимиотерапия

References1

Алоян С. А. Влияние противоопухолевой терапии на микрофлору человека. Молодежь, наука, медицина. 2022. С. 76–79.

Артамонова Е. В. Панитумумаб в терапии метастатического колоректального рака : данные клинических исследований, проблема кожной токсичности. Современная онкология. 2010. Т. 12. №. 3. С. 65.

Артамонова Е. В. Цетуксимаб в терапии метастатического рака толстой кишки : кожная токсичность и пути решения проблемы. Тазовая хирургия и онкология. 2011. №. 3. С. 21–28.

Багдасарян АА, Ших ЕВ. Ассоциация полиморфизма C3435T и риска развития неблагоприятных реакций при фармакотерапии доксорубицином у пациенток с раком молочной железы. Pharmacogenetics and Pharmacogenomics [Internet]. 2023 Apr 3 ; (2) : 7–8. doi: 10.37489/2588-0527-2022-2-7-8.

Багирова А. А. и др. Современные аспекты дерматологии, связанные с побочными действиями таргетных препаратов у больных с онкопатологией. Проблемы современной медицины : актуальные вопросы. 2015. С. 74–78.

Базиков И. А. Сравнительная оценка острой токсичности доксорубицина и его ниосомальной формы. Медицинский вестник северного Кавказа. 2015. Т. 10. №. 4 (38). С. 403–406.

Гончар Н. В. Человек и его микробиота : причины и следствия изменений взаимоотношений (взгляд на проблему). Вопросы детской диетологии. 2015. Т. 13. №. 5. С. 45–54.

Гуляева С. В. Побочные эффекты противоопухолевой химиотерапии. Международный студенческий научный вестник. 2018. №. 4–1. С. 32–34.

Жданова О. С. Микрофлора кожи у больных раком молочной железы в условиях противоопухолевой химиотерапии. Сибирский онкологический журнал. 2005. №. 1. С. 28–31.

Злокачественные новообразования в России в 2021 году (заболеваемость и смертность) М. : МНИОИ им. П.А. Герцена − филиал ФГБУ «НМИЦ радиологии» Минздрава России, − 2022. − илл. − 252 с.

Кетова М. Н. Колонизационная резистентность кожи у больных раком молочной железы на фоне применения кропанола. Сибирский онкологический журнал. 2007. №. 2. С. 46–48.

Когония Л. М. Ладонно-подошвенная эритродизестезия серьезное осложнение при применении капецитабина (собственный опыт). Альманах клинической медицины. 2013. №. 28. С. 37–40.

Королева ИА, Болотина ЛВ, Гладков ОА, Горбунова ВА, Круглова ЛС, Манзюк ЛВ. Практические рекомендации по лекарственному лечению дерматологических реакций у пациентов, получающих противоопухолевую лекарственную терапию. Malignant tumours [Internet]. 2021 Nov 10 ; 11 (3s2–2) : 99–113. doi: 10.18027/2224-5057-2021-11-3s2-42.

Кукош М. Ю. Профилактика поздних лучевых повреждений при проведении химиолучевой терапии. Альманах мировой науки. 2016. №. 3–1. С. 69–72.

Лукьянов А. М. Таргетная терапия немелкоклеточного рака легкого : кожная токсичность. Дерматовенерология. Косметология Учредители : УП» Профессиональные издания». 2022. Т. 8. №. 3. С. 183–202.. doi: 10.34883/pi.2022.8.3.016.

Пахомовская Н. Л., Венедиктова М. М. Влияние микробиоты ребенка первого года жизни на его развитие. Медицинский совет. 2018. №. 2. С. 195–200.

Петербургская С. Лечение и профилактика осложнений химиотерапии препаратами платины и таксанами. Практическая онкология. 2000. Т. 39.

Трещалин И. Д. Модификация токсичности противоопухолевых препаратов как метод повышения эффективности химиотерапии злокачественных новообразований. Российский биотерапевтический журнал. 2005. Т. 4. №. 3. С. 87–94.

Федянин М. Ю., Трякин А. А. Капецитабин и фторурацил в лечении колоректального рака и рака желудка : анализ прямых сравнительных исследований. Фарматека. 2011. Т. 17. С. 20–6.

Agostinetto E, Gligorov J, Piccart M. Systemic therapy for early-stage breast cancer : learning from the past to build the future. Nature Reviews Clinical Oncology [Internet]. 2022 Oct 17 ; 19 (12) : 763–74. doi: 10.1038/s41571-022-00687-1.

Al-Dasooqi N, Sonis ST, Bowen JM, Bateman E, Blijlevens N, et al. Emerging evidence on the pathobiology of mucositis. Supportive Care in Cancer [Internet]. 2013 Jul 11 ; 21 (11) : 3233–41. doi: 10.1007/s00520-013-1900-x.

Al-Mahayri ZN, Patrinos GP, Ali BR. Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy. Frontiers in Pharmacology [Internet]. 2020 Apr 15 ; 11. doi: 10.3389/fphar.2020.00445.

Amjad M. T., Chidharla A., Kasi A. Cancer chemotherapy. 2020.

Anoop TM, Joseph P R, PN M, KP P, Gopan G, Chacko S. Cutaneous Toxicities in Breast Cancer Patients Receiving Chemotherapy and Targeted Agents––An Observational Clinical Study. Clinical Breast Cancer [Internet]. 2021 Aug ; 21 (4) : e434–47. doi: 10.1016/j.clbc.2021.01.009.

Assi S, Torrington E, Cheema E, Hamid AA. Adverse drug reactions associated with chemotherapeutic agents used in breast cancer : Analysis of patients’ online forums. Journal of Oncology Pharmacy Practice [Internet]. 2020 Apr 7 ; 27 (1) : 108–18. doi: 10.1177/1078155220915767.

Azamjah N, Soltan-Zadeh Y, Zayeri F. Global Trend of Breast Cancer Mortality Rate : A 25-Year Study. Asian Pacific Journal of Cancer Prevention [Internet]. 2019 Jul 1 ; 20 (7) : 2015–20. doi: 10.31557/apjcp.2019.20.7.2015.

Azim HA, Agbor-tarh D, Bradbury I, Dinh P, Baselga J, Di Cosimo S, et al. Pattern of Rash, Diarrhea, and Hepatic Toxicities Secondary to Lapatinib and Their Association With Age and Response to Neoadjuvant Therapy : Analysis From the NeoALTTO Trial. Journal of Clinical Oncology [Internet]. 2013 Dec 20 ; 31 (36) : 4504–11. doi: 10.1200/jco.2013.50.9448.

Balkhi B, Alqahtani S, Altayyar W, Ghawaa Y, Alqahtani Z, Alsaleh K, et al. Drug utilization and expenditure of anticancer drugs for breast cancer. Saudi Pharmaceutical Journal [Internet]. 2020 Jun ; 28 (6) : 669–74. doi: 10.1016/j.jsps.2020.04.007.

Basak D, Arrighi S, Darwiche Y, Deb S. Comparison of Anticancer Drug Toxicities : Paradigm Shift in Adverse Effect Profile. Life [Internet]. 2021 Dec 29 ; 12 (1) : 48. doi: 10.3390/life12010048.

Belum VR, Marulanda K, Ensslin C, Gorcey L, Parikh T, Wu S, et al. Alopecia in patients treated with molecularly targeted anticancer therapies. Annals of Oncology [Internet]. 2015 Dec ; 26 (12) : 2496–502. doi: 10.1093/annonc/mdv390.

Beusterien K, Grinspan J, Kuchuk I, Mazzarello S, Dent S, Gertler S, et al. Use of Conjoint Analysis to Assess Breast Cancer Patient Preferences for Chemotherapy Side Effects. The Oncologist [Internet]. 2014 Jan 28 ; 19 (2) : 127–34. doi: 10.1634/theoncologist.2013-0359.

Bilal I, Xie S, Elburki M, Aziziaram Z, Ahmed S, Jalal Balaky ST. Cytotoxic effect of diferuloylmethane, a derivative of turmeric on different human glioblastoma cell lines. Cellular, Molecular and Biomedical Reports [Internet]. 2021 Jun 1 ; 1 (1) : 14–22. doi: 10.55705/cmbr.2021.138815.1004.

Merino Bonilla JA, Torres Tabanera M, Ros Mendoza LH. Breast cancer in the 21<sup>st</sup> century : From early detection to new therapies. Radiología (English Edition) [Internet]. 2017 Sep ; 59 (5) : 368–79. doi: 10.1016/j.rxeng.2017.08.001.

Byrd AL, Belkaid Y, Segre JA. The human skin microbiome. Nature Reviews Microbiology [Internet]. 2018 Jan 15 ; 16 (3) : 143–55. doi: 10.1038/nrmicro.2017.157.

Capone KA, Dowd SE, Stamatas GN, Nikolovski J. Diversity of the Human Skin Microbiome Early in Life. Journal of Investigative Dermatology [Internet]. 2011 Oct ; 131 (10) : 2026–32. doi: 10.1038/jid.2011.168.

Carels N, Spinassé LB, Tilli TM, Tuszynski JA. Toward precision medicine of breast cancer. Theoretical Biology and Medical Modelling [Internet]. 2016 Feb 29 ; 13 (1). doi: 10.1186/s12976-016-0035-4.

Chen P, He G, Qian J, Zhan Y, Xiao R. Potential role of the skin microbiota in Inflammatory skin diseases. Journal of Cosmetic Dermatology [Internet]. 2020 Jun 20 ; 20 (2) : 400–9. doi: 10.1111/jocd.13538.

Chen YE, Fischbach MA, Belkaid Y. Skin microbiota–host interactions. Nature [Internet]. 2018 Jan 25 ; 553 (7689) : 427–36. doi: 10.1038/nature25177.

Chu DM, Ma J, Prince AL, Antony KM, Seferovic MD, Aagaard KM. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nature Medicine [Internet]. 2017 Jan 23 ; 23 (3) : 314–26. doi: 10.1038/nm.4272.

Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota : a major player in the toxicity of environmental pollutants? npj Biofilms and Microbiomes [Internet]. 2016 May 4 ; 2 (1). doi: 10.1038/npjbiofilms.2016.3.

Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proceedings of the National Academy of Sciences [Internet]. 2009 Aug 25 ; 106 (34) : 14728–33. doi: 10.1073/pnas.0904489106.

Cremante M, Pastorino A, Ponzano M, Grassi M, Martelli V, Puccini A, et al. Reliability of patient-reported toxicities during adjuvant chemotherapy. European Journal of Cancer [Internet]. 2023 Mar ; 182 : 115–21. doi: 10.1016/j.ejca.2023.01.005.

Dagnelie M, Corvec S, Timon-David E, Khammari A, Dréno B. Cutibacterium acnes and Staphylococcus epidermidis : the unmissable modulators of skin inflammatory response. Experimental Dermatology [Internet]. 2021 Nov 5 ; 31 (3) : 406–12. doi: 10.1111/exd.14467.

Dagnelie M, Montassier E, Khammari A, Mounier C, Corvec S, Dréno B. Inflammatory skin is associated with changes in the skin microbiota composition on the back of severe acne patients. Experimental Dermatology [Internet]. 2019 Jul 3 ; 28 (8) : 961–7. doi: 10.1111/exd.13988.

Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proceedings of the National Academy of Sciences [Internet]. 2010 Jun 21 ; 107 (26) : 11971–5. doi: 10.1073/pnas.1002601107.

Dréno B, Pécastaings S, Corvec S, Veraldi S, Khammari A, Roques C. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris : a brief look at the latest updates. Journal of the European Academy of Dermatology and Venereology [Internet]. 2018 Jun ; 32 : 5–14. doi: 10.1111/jdv.15043.

Dréno B, Dagnelie MA, Khammari A, Corvec S. The Skin Microbiome : A New Actor in Inflammatory Acne. American Journal of Clinical Dermatology [Internet]. 2020 Sep ; 21 (S1) : 18–24. doi: 10.1007/s40257-020-00531-1.

Fahad Ullah M. Breast Cancer : Current Perspectives on the Disease Status. Breast Cancer Metastasis and Drug Resistance [Internet]. 2019 ; 51–64. doi: 10.1007/978-3-030-20301-6_4.

Ferček I, Lugović-Mihić L, Tambić-Andrašević A, Ćesić D, Grginić AG, Bešlić I, et al. Features of the Skin Microbiota in Common Inflammatory Skin Diseases. Life [Internet]. 2021 Sep 14 ; 11 (9) : 962. doi: 10.3390/life11090962.

Findley K, Oh J, Yang J, Conlan S, Deming C, et al. Topographic diversity of fungal and bacterial communities in human skin. Nature [Internet]. 2013 May 22 ; 498 (7454) : 367–70. doi: 10.1038/nature12171.

Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, et al. Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations. New England Journal of Medicine [Internet]. 2012 Nov ; 367 (18) : 1694–703. doi: 10.1056/nejmoa1210093.

Flowers L, Grice EA. The Skin Microbiota : Balancing Risk and Reward. Cell Host &amp ; Microbe [Internet]. 2020 Aug ; 28 (2) : 190–200. doi: 10.1016/j.chom.2020.06.017.

Gaitanis G, Tsiouri G, Spyridonos P, Stefos Τ, Stamatas GN, Velegraki A, et al. Variation of cultured skin microbiota in mothers and their infants during the first year postpartum. Pediatric Dermatology [Internet]. 2019 Apr 25 ; doi: 10.1111/pde.13829.

Gozzo T de O, Panobianco MS, Clapis MJ, Almeida AM de. Dermatological Toxicity in Women With Breast Cancer Undergoing Chemotherapy Treatment. Revista Latino-Americana de Enfermagem [Internet]. 2010 Aug ; 18 (4) : 681–7. doi: 10.1590/s0104-11692010000400004.

Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, et al. Topographical and Temporal Diversity of the Human Skin Microbiome. Science [Internet]. 2009 May 29; 324 (5931) : 1190–2. doi: 10.1126/science.1171700.

Grimaldi AM, Simeone E, Festino L, Vanella V, Strudel M, Ascierto PA. MEK Inhibitors in the Treatment of Metastatic Melanoma and Solid Tumors. American Journal of Clinical Dermatology [Internet]. 2017 May 23 ; 18 (6) : 745–54. doi: 10.1007/s40257-017-0292-y.

Haidinger R, Bauerfeind I. Long-Term Side Effects of Adjuvant Therapy in Primary Breast Cancer Patients : Results of a Web-Based Survey. Breast Care [Internet]. 2019 ; 14 (2) : 111–6. doi: 10.1159/000497233.

Hannigan GD, Meisel JS, Tyldsley AS, Zheng Q, Hodkinson BP, SanMiguel AJ, et al. The Human Skin Double-Stranded DNA Virome : Topographical and Temporal Diversity, Genetic Enrichment, and Dynamic Associations with the Host Microbiome. Heitman J, editor. mBio [Internet]. 2015 Oct 30 ; 6 (5). doi: 10.1128/mbio.01578-15.

Heil J, Kuerer HM, Pfob A, Rauch G, Sinn HP, Golatta M, et al. Eliminating the breast cancer surgery paradigm after neoad-juvant systemic therapy : current evidence and future challenges. Annals of Oncology [Internet]. 2020 Jan ; 31 (1) : 61–71. doi: 10.1016/j.annonc.2019.10.012.

Heo YS, Chang HM, Kim TW, Ryu M-H, Ahn J-H, Kim SB, et al. Hand-Foot Syndrome in Patients Treated With Capecitabine-Containing Combination Chemotherapy. The Journal of Clinical Pharmacology [Internet]. 2004 Oct ; 44 (10) : 1166–72. doi: 10.1177/0091270004268321.

HOLT R. THE BACTERIAL DEGRADATION OF CHLORAMPHENICOL. The Lancet [Internet]. 1967 Jun ; 289 (7502) : 1259–60. doi: 10.1016/s0140-6736(67)92720-1.

Hong J, Park SH, Choi SJ, Lee SH, Lee KC, Lee J-I, et al. Nail Toxicity after Treatment with Docetaxel : A Prospective Analysis in Patients with Advanced Non-small Cell Lung Cancer. Japanese Journal of Clinical Oncology [Internet]. 2007 Jun 1 ; 37 (6) : 424–8. doi: 10.1093/jjco/hym042.

Ito Y, Amagai M. Dissecting skin microbiota and microenvironment for the development of therapeutic strategies. Current Opinion in Microbiology [Internet]. 2023 Aug ; 74 : 102311. doi: 10.1016/j.mib.2023.102311.

Joseph K, Vrouwe S, Kamruzzaman A, Balbaid A, Fenton D, Berendt R, et al. Outcome analysis of breast cancer patients who declined evidence-based treatment. World Journal of Surgical Oncology [Internet]. 2012 Jun 26 ; 10 (1). doi: 10.1186/1477-7819-10-118.

Kolesnik OP, Kadzhoian AV, Kabakov AO. State of care in patients with cervical cancer in Zaporozhzhia region since 2008 to 2015 year. Pathologia [Internet]. 2016 Oct 27 ; 0 (2). doi: 10.14739/2310-1237.2016.2.80893.

Koontz JM, Dancy BCR, Horton CL, Stallings JD, DiVito VT, Lewis JA. The Role of the Human Microbiome in Chemical Toxicity. International Journal of Toxicology [Internet]. 2019 Jun 20 ; 38 (4) : 251–64. doi: 10.1177/1091581819849833.

Korde LA, Somerfield MR, Carey LA, Crews JR, Denduluri N, Hwang ES, et al. Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer : ASCO Guideline. Journal of Clinical Oncology [Internet]. 2021 May 1;39(13):1485–505. doi: 10.1200/jco.20.03399.

Lee WJ, Lee JL, Chang SE, Lee MW, Kang YK, Choi JH, et al. Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib. British Journal of Dermatology [Internet]. 2009 Nov ; 161 (5) : 1045–51. doi: 10.1111/j.1365-2133.2009.09290.x.

Leung MHY, Wilkins D, Lee PKH. Insights into the pan-microbiome : skin microbial communities of Chinese individuals differ from other racial groups. Scientific Reports [Internet]. 2015 Jul 16 ; 5 (1). doi: 10.1038/srep11845.

Li W, Yosipovitch G. The Role of the Microbiome and Microbiome-Derived Metabolites in Atopic Dermatitis and Non-Histaminergic Itch. American Journal of Clinical Dermatology [Internet]. 2020 Sep ; 21 (S1) : 44–50. doi: 10.1007/s40257-020-00538-8.

Liu Y-Q, Wang X-L, He D-H, Cheng Y-X. Protection against chemotherapy- and radiotherapy-induced side effects : A review based on the mechanisms and therapeutic opportunities of phytochemicals. Phytomedicine [Internet]. 2021 Jan ; 80 : 153402. doi: 10.1016/j.phymed.2020.153402.

Majem M, Moreno ME, Calvo N, Feliu A, Pérez J, Mangues MA, et al. Perception of healthcare providers versus patient reported incidence of chemotherapy-induced nausea and vomiting after the addition of NK-1 receptor antagonists. Supportive Care in Cancer [Internet]. 2010 Nov 18 ; 19 (12) : 1983–90. doi: 10.1007/s00520-010-1042-3.

Momenimovahed Z, Salehiniya H. &lt ; p&gt ; Epidemiological characteristics of and risk factors for breast cancer in the world&lt ; / p&gt ; Breast Cancer : Targets and Therapy [Internet]. 2019 Apr;Volume 11:151–64. doi: 10.2147/bctt.s176070.

Moo T-A, Sanford R, Dang C, Morrow M. Overview of Breast Cancer Therapy. PET Clinics [Internet]. 2018 Jul ; 13 (3) : 339–54. doi: 10.1016/j.cpet.2018.02.006.

Moth EB, Kiely BE, Stefanic N, et al. Predicting chemotherapy toxicity in older adults : comparing the predictive value of the CARG Toxicity Score with oncologists’ estimates of toxicity based on clinical judgement. J Geriatr Oncol 2019 ; 10 : 202–9.

Nakamura ZM, Deal AM, Nyrop KA, Chen YT, Quillen LJ, Brenizer T, et al. Serial Assessment of Depression and Anxiety by Patients and Providers in Women Receiving Chemotherapy for Early Breast Cancer. The Oncologist [Internet]. 2020 Oct 2 ; 26 (2) : 147–56. doi: 10.1002/onco.13528.

Niu H-Y, Niu C-Y, Wang J-H, Zhang Y, He P. Health-related Quality of Life in Women with Breast Cancer : a Literature-based Review of Psychometric Properties of Breast Cancer-specific Measures. Asian Pacific Journal of Cancer Prevention [Internet]. 2014 Apr 30 ; 15 (8) : 3533–6. doi: 10.7314/apjcp.2014.15.8.3533.

Oh J, Conlan S, Polley EC, Segre JA, Kong HH. Shifts in human skin and nares microbiota of healthy children and adults. Genome Medicine [Internet]. 2012 ; 4 (10) : 77. doi: 10.1186/gm378.

Oh J, Byrd AL, Park M, Kong HH, Segre JA. Temporal Stability of the Human Skin Microbiome. Cell [Internet]. 2016 May ; 165 (4) : 854–66. doi: 10.1016/j.cell.2016.04.008.

Osio A, Mateus C, Soria J-C, Massard C, Malka D, Boige V, et al. Cutaneous side-effects in patients on long-term treatment with epidermal growth factor receptor inhibitors. British Journal of Dermatology [Internet]. 2009 Sep ; 161 (3) : 515–21. doi: 10.1111/j.1365-2133.2009.09214.x.

O’Sullivan JN, Rea MC, O’Connor PM, Hill C, Ross RP. Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens. FEMS Microbiology Ecology [Internet]. 2018 Dec 24 ; 95 (2). doi: 10.1093/femsec/fiy241.

Pagani M, Bavbek S, Alvarez-Cuesta E, Berna Dursun A, Bonadonna P, Castells M, et al. Hypersensitivity reactions to chemotherapy : an EAACI Position Paper. Allergy [Internet]. 2021 Oct 26 ; 77 (2) : 388–403. doi: 10.1111/all.15113.

Pammi M, O’Brien JL, Ajami NJ, Wong MC, Versalovic J, Petrosino JF. Development of the cutaneous microbiome in the preterm infant : A prospective longitudinal study. Wilson BA, editor. PLOS ONE [Internet]. 2017 Apr 27 ; 12 (4) : e0176669. doi: 10.1371/journal.pone.0176669.

Pastrana DV, Peretti A, Welch NL, Borgogna C, Olivero C, Badolato R, et al. Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency. Imperiale MJ, editor. mSphere [Internet]. 2018 Dec 26 ; 3 (6). doi: 10.1128/mspheredirect.00645-18.

Polyak K. Breast cancer : origins and evolution. Journal of Clinical Investigation [Internet]. 2007 Nov 1 ; 117 (11) : 3155–63. doi: 10.1172/jci33295.

Potthoff K, Hofheinz R, Hassel JC, Volkenandt M, Lordick F, Hartmann JT, et al. Interdisciplinary management of EGFR-inhibitor-induced skin reactions : a German expert opinion. Annals of Oncology [Internet]. 2011 Mar ; 22 (3) : 524–35. doi: 10.1093/annonc/mdq387.

Prieto-Callejero B, Rivera F, Fagundo-Rivera J, Romero A, Romero-Martín M, Gómez-Salgado J, et al. Relationship between chemotherapy-induced adverse reactions and health-related quality of life in patients with breast cancer. Medicine [Internet]. 2020 Aug 14 ; 99 (33) : e21695. doi: 10.1097/md.0000000000021695.

Ramasamy S, Barnard E, Dawson TL, Li H. The role of the skin microbiota in acne pathophysiology. British Journal of Dermatology [Internet]. 2019 Jul 24 ; 181 (4) : 691–9. doi: 10.1111/bjd.18230.

Rey-Vargas L, Mejía-Henao JC, Sanabria-Salas MC, Serrano-Gomez SJ. Effect of neoadjuvant therapy on breast cancer biomarker profile. BMC Cancer [Internet]. 2020 Jul 18 ; 20 (1). doi: 10.1186/s12885-020-07179-4.

Richardson BN, Lin J, Buchwald ZS, Bai J. Skin Microbiome and Treatment-Related Skin Toxicities in Patients With Cancer : A Mini-Review. Frontiers in Oncology [Internet]. 2022 Jul 15 ; 12. doi: 10.3389/fonc.2022.924849.

Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, et al. A common classification framework for neuroendocrine neoplasms : an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Modern Pathology [Internet]. 2018 Dec ; 31 (12) : 1770–86. doi: 10.1038/s41379-018-0110-y.

Robert C, Sibaud V, Mateus C, Verschoore M, Charles C, Lanoy E, et al. Nail toxicities induced by systemic anticancer treatments. The Lancet Oncology [Internet]. 2015 Apr ; 16 (4) : e181–9. doi: 10.1016/s1470-2045(14)71133-7.

Salzmann M, Marmé F, Hassel JC. Prophylaxis and Management of Skin Toxicities. Breast Care [Internet]. 2019 ; 14 (2) : 72–7. doi: 10.1159/000497232.

Schneider AM, Nelson AM. Skin microbiota : Friend or foe in pediatric skin health and skin disease. Pediatric Dermatology [Internet]. 2019 Oct 6 ; 36 (6) : 815–22. doi: 10.1111/pde.13955.

Selli C, Sims AH. Neoadjuvant Therapy for Breast Cancer as a Model for Translational Research. Breast Cancer : Basic and Clinical Research [Internet]. 2019 Jan ; 13 : 117822341982907. doi: 10.1177/1178223419829072.

Shibagaki N, Suda W, Clavaud C, Bastien P, Takayasu L, Iioka E, et al. Aging-related changes in the diversity of women’s skin microbiomes associated with oral bacteria. Scientific Reports [Internet]. 2017 Sep 5 ; 7 (1). doi: 10.1038/s41598-017-10834-9.

Shien T, Iwata H. Adjuvant and neoadjuvant therapy for breast cancer. Japanese Journal of Clinical Oncology [Internet]. 2020 Jan 28 ; 50 (3) : 225–9. doi: 10.1093/jjco/hyz213.

Skowron K, Bauza-Kaszewska J, Kraszewska Z, Wiktorczyk-Kapischke N, Grudlewska-Buda K, Kwiecińska-Piróg J, et al. Human Skin Microbiome : Impact of Intrinsic and Extrinsic Factors on Skin Microbiota. Microorganisms [Internet]. 2021 Mar 5 ; 9 (3) : 543. doi: 10.3390/microorganisms9030543.

Smith RV. Metabolism of Drugs and Other Foreign Compounds by Intestinal Microorganisms. World Review of Nutrition and Dietetics [Internet]. : 60–76. doi: 10.1159/000400751.

100

Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy-induced mucosal injury. Cancer [Internet]. 2004 ; 100 (S9) : 1995–2025. doi: 10.1002/cncr.20162.

101

Tirosh O, Conlan S, Deming C, Lee-Lin S-Q, Huang X, et al. Expanded skin virome in DOCK8-deficient patients. Nature Medicine [Internet]. 2018 Nov 5 ; 24 (12) : 1815–21. doi: 10.1038/s41591-018-0211-7.

102

Tolotti A, Bonetti L, Bordoni A, Prieto-Casais N, Moser L, Sari D, et al. Nursing management of fatigue in cancer patients : Mixed methods study. Annals of Oncology [Internet]. 2019 Oct ; 30 : v844. doi: 10.1093/annonc/mdz276.031.

103

Tomic-Canic M, Burgess JL, O’Neill KE, Strbo N, Pastar I. Skin Microbiota and its Interplay with Wound Healing. American Journal of Clinical Dermatology [Internet]. 2020 Sep ; 21 (S1) : 36–43. doi: 10.1007/s40257-020-00536-w.

104

Trüeb RM. Chemotherapy-induced alopecia. Current Opinion in Supportive &amp ; Palliative Care [Internet]. 2010 Dec ; 4 (4) : 281–4. doi: 10.1097/spc.0b013e3283409280.

105

Waks AG, Winer EP. Breast Cancer Treatment. JAMA [Internet]. 2019 Jan 22 ; 321 (3) : 288. doi: 10.1001/jama.2018.19323.

106

Wang Y, Zhang R, Shen Y, Su L, Dong B, Hao Q. &lt ; p&gt ; Prediction of chemotherapy adverse reactions and mortality in older patients with primary lung cancer through frailty index based on routine laboratory data&lt ; / p&gt ; Clinical Interventions in Aging [Internet]. 2019 Jul ; Volume 14 : 1187–97. doi: 10.2147/cia.s201873.

107

Watkins EJ. Overview of breast cancer. JAAPA [Internet]. 2019 Oct ; 32 (10) : 13–7. doi: 10.1097/01.jaa.0000580524.95733.3d.

108

Wolters R, Regierer AC, Schwentner L, Geyer V, Possinger K, Kreienberg R, et al. A comparison of international breast cancer guidelines – Do the national guidelines differ in treatment recommendations? European Journal of Cancer [Internet]. 2012 Jan;48(1):1–11. doi: 10.1016/j.ejca.2011.06.020.

109

Yang JC-H, Wu Y-L, Schuler M, Sebastian M, Popat S, Yamamoto N, et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6) : analysis of overall survival data from two randomised, phase 3 trials. The Lancet Oncology [Internet]. 2015 Feb ; 16 (2) : 141–51. doi: 10.1016/s1470-2045(14)71173-8.

110

Ying S, Zeng D-N, Chi L, Tan Y, Galzote C, Cardona C, et al. The Influence of Age and Gender on Skin-Associated Microbial Communities in Urban and Rural Human Populations. Badger JH, editor. PLOS ONE [Internet]. 2015 Oct 28 ; 10 (10) : e0141842. doi: 10.1371/journal.pone.0141842

111

Zhou H, Shi L, Ren Y, Tan X, Liu W, Liu Z. Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy. Frontiers in Cellular and Infection Microbiology [Internet ]. 2020 Oct 22 ; 10. doi: 10.3389/fcimb.2020.570261

The authors declare that there are no conflicts of interest present.