tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2023-13-3-49-55tumors-1168Research ArticleОБЗОРЫ И АНАЛИТИКАREVIEWS AND ANALYSISХирургическое лечение рецидивной внутрипеченочной холангиокарциномы (систематический обзор литературы)Surgical treatment of recurrent intrahepatic cholangiocarcinoma (systematic review)БрицкаяН. Н.BritskayaN.  N.

Наталья Н. Брицкая, к. м. н., соискатель

Москва

Natalia N. Britskaya, MD, PhD, applicant

Moscow

britska_surg@mail.ruФисенкоД. В.FisenkoD.  V.

Денис В. Фисенко, младший научный сотрудник отдела гепатопанкреатобилиарной хирургии

Москва

Denis V. Fisenko, junior researcher of the Department of Hepato-pancreato-biliary Surgery

Moscow

d.fisenko@mknc.ruЕфановМ. Г.EfanovM.  G.

Михаил Г. Ефанов, д. м. н., руководитель отдела гепатопанкреатобилиарной хирургии

Москва

Mikhail G. Efanov, MD, PhD, DSc, Head of the Department of Hepato-pancreato-biliary Surgery

Moscow

m.efanov@mknc.ruГБУЗ «МКНЦ имени А.С. Логинова» ДЗМРоссияMoscow Clinical Scientific Center named after A. S. LoginovRussian Federation2023081120231334955Copyright © Брицкая Н.Н., Фисенко Д.В., Ефанов М.Г., 20232023Брицкая Н.Н., Фисенко Д.В., Ефанов М.Г.Britskaya N.N., Fisenko D.V., Efanov M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/1168Актуальность

Актуальность: Резекция печени при внутрипеченочной холангиокрациноме сопровождается высокой частотой рецидивов (до 70%) в первые 2 года после операции. Результаты лечения рецидивной опухоли оцениваются противоречиво.

Цель

Цель: Анализ результатов повторных резекций печени и методов локорегионарной терапии рецидивов внутрипеченочной холангиокарциномы на основании данных литературы.

Материалы и методы

Материалы и методы: Поиск источников производился в системах PubMed и Google Scholar. В написании обзора литературы использованы 35 источников, опубликованных с 2010 г. по 2022 г.

Результаты

Результаты: Повторные резекции печени с последующей химиотерапией обеспечивают лучшие отдаленные результаты лечения в сравнении с другими методами локальной терапии и системного лекарственного лечения. Частота периоперационных осложнений не отличается от таковых после резекций при первичных опухолях. Выполнение повторной резекции печени возможно у ограниченного числа пациентов (8–10%). Необходима тщательная селекция больных с учетом прогноза и биологического поведения опухоли.

Заключение

Заключение: Доказательства преимущества повторных резекций в лечении рецидива внутрипеченочной холангиокарциномы построены на небольшом числе исследований, анализировавших относительно небольшие и неоднородные выборки пациентов. Необходим отбор больных, критерии которого продолжают обсуждаться.

Background

Background: Liver resection for intrahepatic cholangiocarcinoma is accompanied by a high recurrence rate (up to 70 %) in the first 2 years after surgery. The results of treatment of recurrent intrahepatic cholangiocarcinoma are evaluated inconsistently.

Aim

Aim: The results of repeated liver resections and methods of locoregional therapy for reccurent intrahepatic cholangiocarcinoma were analysed based on literature data.

Materials and methods

Materials and methods: Two publication databases have been used for search: PubMed and Google Scholar. Finally, 35 papers published from 2010 to 2022 were included in review.

Results

Results: Repeated liver resections followed by chemotherapy provide better long-term results compared to other methods of local therapy and systemic drug treatment. The rate of perioperative morbidity does not differ from resections for primary tumors. Repeat liver resection is possible in a limited number of patients (8–10 %). Thorough selection of patients is necessary in terms of prognosis and biological behavior of the tumor.

Conclusion

Conclusion: Evidence for the benefit of resections in the treatment of recurrent intrahepatic cholangiocarcinoma is based on a scarse number of studies analyzing relatively small and heterogeneous patient cohorts. Patient selection is needed, the criteria for which are still being discussed.

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The authors declare that there are no conflicts of interest present.